Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Clarithromycin
Drug ID BADD_D00480
Description Clarithromycin, a semisynthetic macrolide antibiotic derived from erythromycin, inhibits bacterial protein synthesis by binding to the bacterial 50S ribosomal subunit. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the translation and protein assembly process. Clarithromycin may be bacteriostatic or bactericidal depending on the organism and drug concentration.
Indications and Usage An alternative medication for the treatment of acute otitis media caused by H. influenzae, M. catarrhalis, or S. pneumoniae in patients with a history of type I penicillin hypersensitivity. Also for the treatment of pharyngitis and tonsillitis caused by susceptible Streptococcus pyogenes, as well as respiratory tract infections including acute maxillary sinusitis, acute bacterial exacerbations of chronic bronchitis, mild to moderate community-acquired pneuomia, Legionnaires' disease, and pertussis. Other indications include treatment of uncomplicated skin or skin structure infections, helicobacter pylori infection, duodenal ulcer disease, bartonella infections, early Lyme disease, and encephalitis caused by Toxoplasma gondii (in HIV infected patients in conjunction with pyrimethamine). Clarithromycin may also decrease the incidence of cryptosporidiosis, prevent the occurence of α-hemolytic (viridans group) streptococcal endocarditis, as well as serve as a primary prevention for Mycobacterium avium complex (MAC) bacteremia or disseminated infections (in adults, adolescents, and children with advanced HIV infection).
Marketing Status Prescription; Discontinued
ATC Code J01FA09
DrugBank ID DB01211
KEGG ID D00276
MeSH ID D017291
PubChem ID 84029
NDC Product Code 62135-616; 62332-344; 50090-5282; 43063-752; 70934-507; 50090-4059; 62135-615; 62991-2687; 68071-3116; 0527-1931; 63415-0018; 64679-949; 67296-1632; 49452-2112; 27241-065; 63629-8222; 0781-6023; 38779-1937; 71335-1567; 67296-0464; 60592-429; 43063-823; 50268-178; 57237-045; 76420-051; 61919-643; 71335-0795; 68788-7933; 63629-7832; 68071-5045; 0527-1932; 65862-225; 60687-435; 63187-625; 50268-179; 64679-954; 65862-226; 50090-1830; 43063-520; 71335-0017; 50090-0994; 0781-1961; 27241-064; 67296-1360; 64380-905; 50090-5285; 0904-6872; 46708-829; 43063-942; 70934-905; 51552-1566; 0781-1962; 50090-2441; 43063-565; 43781-0403; 59566-0123; 70518-2773; 15894-0026; 63187-376; 64380-906; 71335-1493; 46708-839; 57237-044; 0395-8158; 0781-6022; 67296-1072; 0051-6552; 70934-530; 51862-194; 0591-2805; 50090-2515; 0527-1930; 53002-7561; 62332-345; 63629-6763; 43063-530; 68788-7125; 43666-0001; 72189-299; 65096-0100
Synonyms Clarithromycin | 6-O-Methylerythromycin | TE-031 | TE 031 | TE031 | A-56268 | A 56268 | A56268 | Biaxin
Chemical Information
Molecular Formula C38H69NO13
CAS Registry Number 81103-11-9
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Torsade de pointesPotassium voltage-gated channel subfamily H member 2Q12809T2025110219239; 10984545; 10868744
Torsade de pointesPotassium voltage-gated channel subfamily KQT member 1P51787T4952610219239; 10984545; 10868744
Torsade de pointesMisshapen-like kinase 1Q8N4C8Not Available10219239; 10984545; 10868744
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal distension07.01.04.0010.003290%
Abdominal pain07.01.05.0020.017274%
Abdominal pain lower07.01.05.0100.002056%Not Available
Abdominal pain upper07.01.05.0030.015629%
Abdominal tenderness07.01.05.0040.000823%Not Available
Abnormal dreams19.02.03.001; Available
Abnormal faeces07.01.03.0010.000823%Not Available
Abnormal weight gain14.03.02.0100.000823%Not Available
Abortion spontaneous18.01.04.0010.117626%Not Available
Abscess11.01.08.0010.001234%Not Available
Acne23.02.01.001--Not Available
Acquired immunodeficiency syndrome11.05.17.007; Available
Acute disseminated encephalomyelitis17.16.02.003; Available
Acute hepatic failure09.01.03.0010.002056%Not Available
Acute psychosis19.03.01.0010.003702%Not Available
Acute respiratory distress syndrome22.01.03.0010.000823%
Acute respiratory failure22.02.06.001; Available
Adrenal insufficiency14.11.01.004;
Ageusia17.02.07.001; Available
Aggression19.05.01.0010.003702%Not Available
Agranulocytosis01.02.03.0010.001234%Not Available
Alanine aminotransferase13.03.01.031--Not Available
Alanine aminotransferase increased13.03.01.003--
Albumin globulin ratio abnormal13.09.01.011--Not Available
Altered state of consciousness19.07.01.003; Available
Ammonia increased13.03.01.0230.000823%Not Available
Amylase increased13.05.01.009--
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