Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cefotaxime
Drug ID BADD_D00390
Description Cefotaxime is a third-generation cephalosporin antibiotic. Like other third-generation cephalosporins, it has broad spectrum activity against Gram positive and Gram negative bacteria. In most cases, it is considered to be equivalent to ceftriaxone in terms of safety and efficacy. Cefotaxime sodium is marketed under various trade names including Claforan (Sanofi-Aventis).
Indications and Usage Used to treat gonorrhoea, meningitis, and severe infections including infections of the kidney (pyelonephritis) and urinary system. Also used before an operation to prevent infection after surgery.
Marketing Status Prescription; Discontinued
ATC Code J01DD01
DrugBank ID DB00493
KEGG ID D07647
MeSH ID D002439
PubChem ID 5742673
TTD Drug ID D0D1HA
NDC Product Code 0143-9933; 0143-9930; 0143-9935; 0143-9931
Synonyms Cefotaxime | Cephotaxim | Cefotaxim | Biosint | Cefotaxime Sodium | Sodium, Cefotaxime | Cefradil | Taporin | Fotexina | HR-756 | HR 756 | HR756 | Kendrick | Ru-24756 | Ru 24756 | Ru24756 | Benaxima | Claforan | Primafen | Klaforan
Chemical Information
Molecular Formula C16H17N5O7S2
CAS Registry Number 63527-52-6
SMILES CC(=O)OCC1=C(N2C(C(C2=O)NC(=O)C(=NOC)C3=CSC(=N3)N)SC1)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Agranulocytosis01.02.03.0010.000319%Not Available
Alanine aminotransferase increased13.03.01.003--
Anaemia01.03.02.0010.000426%
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Anaphylactic shock24.06.02.004; 10.01.07.0020.000639%Not Available
Angina pectoris02.02.02.002; 24.04.04.0020.000319%
Angioedema23.04.01.001; 10.01.05.009--Not Available
Aplastic anaemia01.03.03.002--Not Available
Arrhythmia02.03.02.0010.000319%Not Available
Aspartate aminotransferase increased13.03.01.0060.000319%
Asthenia08.01.01.0010.000319%Not Available
Blood iron decreased13.11.01.0060.000319%Not Available
Blood lactate dehydrogenase increased13.04.02.002--
Body temperature increased13.15.01.001--Not Available
Bronchospasm10.01.03.012; 22.03.01.004--
C-reactive protein increased13.09.01.0070.000319%Not Available
Chills15.05.03.016; 08.01.09.0010.000319%
Cholestasis09.01.01.0010.000319%Not Available
Clostridium difficile colitis11.02.02.004; 07.19.01.0040.000083%Not Available
Colitis07.08.01.001--
Cyanosis24.03.01.007; 22.02.02.007; 02.01.02.0020.000213%
Dermatitis23.03.04.002--Not Available
Dermatitis bullous23.03.01.002--
Diarrhoea07.02.01.001--
Discomfort08.01.08.003--Not Available
Dizziness17.02.05.003; 02.01.02.004; 24.06.02.0070.000532%
Drug hypersensitivity10.01.01.0010.000319%Not Available
Electrocardiogram QT prolonged13.14.05.0040.000426%
Encephalitis17.06.05.001; 11.01.03.0080.000639%
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