Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Pulmonary fibrosis
ADR ID BADD_A03633
ADR Hierarchy
22      Respiratory, thoracic and mediastinal disorders
22.01      Lower respiratory tract disorders (excl obstruction and infection)
22.01.02      Parenchymal lung disorders NEC
22.01.02.006      Pulmonary fibrosis
Description A disorder characterized by the replacement of the lung tissue by connective tissue, leading to progressive dyspnea, respiratory failure or right heart failure. [CTCAE] A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death. [MeSH]
MedDRA Code 10037383
MeSH ID D011658
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Fibrosis lung | Fibrosis pulmonary | Lung fibrosis | Other pulmonary fibroses NOS | Postinflammatory pulmonary fibrosis | Pulmonary fibrosis | Pulmonary fibrosis (post inflammatory) | Pulmonary sclerosis | Post inflammatory pulmonary fibrosis | Lung scarring | Pulmonary Fibrosis | Pulmonary Fibroses | Fibroses, Pulmonary | Fibrosis, Pulmonary | Alveolitis, Fibrosing | Alveolitides, Fibrosing | Fibrosing Alveolitides | Fibrosing Alveolitis | Hamman-Rich Syndrome | Hamman Rich Syndrome | Syndrome, Hamman-Rich
ADR Related Proteins
Protein Name UniProt AC TTD Target ID
Collagen alpha-1(I) chainP02452Not Available
Granulocyte-macrophage colony-stimulating factorP04141T74002
Interleukin-1 betaP01584T42000
Interleukin-6P05231T32578
Superoxide dismutase [Cu-Zn]P00441T22977
Tumor necrosis factorP01375T20178
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00014Abiraterone--
BADD_D00041Adalimumab--
BADD_D00047Afatinib--
BADD_D00066Alendronic acid--
BADD_D00076Allopurinol--
BADD_D00100Ambrisentan--
BADD_D00115Amiodarone--
BADD_D00116Amiodarone hydrochloride--
BADD_D00139Anagrelide--
BADD_D00151Apixaban--
BADD_D00156Apremilast--
BADD_D00178Atenolol--
BADD_D00194Azacitidine--
BADD_D00195Azathioprine--
BADD_D00230Bendamustine--
BADD_D00231Bendamustine hydrochloride--
BADD_D00271Bicalutamide--
BADD_D00277Bisoprolol--
BADD_D00280Bleomycin--
BADD_D00281Bleomycin sulfate--
BADD_D00284Bortezomib--
BADD_D00285Bosentan--
BADD_D00304Bromocriptine--
BADD_D00305Bromocriptine mesylate--
BADD_D00306Budesonide--
BADD_D00318Busulfan--
BADD_D00329Cabergoline--
BADD_D00349Capecitabine--
BADD_D00364Carboplatin--
BADD_D00367Carfilzomib--
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