Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Bleomycin
Drug ID BADD_D00280
Description A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2 (B2 CAS # 9060-10-0). It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors. Bleomycin A2 is used as the representative structure for Bleomycin.
Indications and Usage For palliative treatment in the management malignant neoplasm (trachea, bronchus, lung), squamous cell carcinoma, and lymphomas.
Marketing Status Prescription; Discontinued
ATC Code L01DC01
DrugBank ID DB00290
KEGG ID D07535
MeSH ID D001761
PubChem ID 5460769
TTD Drug ID D06UVD
NDC Product Code 61703-323; 0143-9240; 0703-3155; 16714-908; 0409-0332; 61703-332; 16714-886; 0143-9241; 70121-1567; 0703-3154; 0409-0323; 69097-364
Synonyms Bleomycin | Bleomycins | BLEO-cell | BLEO cell | BLEOcell | Bleolem | Bléomycine Bellon | Bellon, Bléomycine | Bleomycin A2 | Bleomycin A(2) | Bleomycin B2 | Bleomycin B(2) | Bleomycin Sulfate | Sulfate, Bleomycin | Bleomycinum Mack | Mack, Bleomycinum | Blenoxane | Blanoxan | Bleomicina
Chemical Information
Molecular Formula C55H84N17O21S3+
CAS Registry Number 11056-06-7
SMILES CC1=C(N=C(N=C1N)C(CC(=O)N)NCC(C(=O)N)N)C(=O)NC(C(C2=CN=CN2)OC3C(C(C(C(O3)CO)O)O) OC4C(C(C(C(O4)CO)O)OC(=O)N)O)C(=O)NC(C)C(C(C)C(=O)NC(C(C)O)C(=O)NCCC5=NC(=CS5)C6 =NC(=CS6)C(=O)NCCC[S+](C)C)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Acute hepatic failure09.01.03.0010.000533%Not Available
Acute myeloid leukaemia16.01.05.001; 01.10.05.0010.000208%Not Available
Acute respiratory distress syndrome22.01.03.0010.000417%
Aggression19.05.01.001--Not Available
Akinesia17.01.02.0030.000533%Not Available
Alopecia23.02.02.0010.001066%
Alveolitis allergic22.01.01.002; 10.01.03.0080.000533%Not Available
Anaemia01.03.02.0010.002131%
Anaphylactic shock10.01.07.002; 24.06.02.004--Not Available
Arteritis24.05.01.001--Not Available
Arthritis15.01.01.001--
Asthenia08.01.01.001--Not Available
Azoospermia21.03.03.0010.001598%
Bladder pain20.02.02.001--Not Available
Blister23.03.01.001; 12.01.06.0020.001066%Not Available
Body temperature increased13.15.01.001--Not Available
Bronchospasm22.03.01.004; 10.01.03.012--
Cardiomyopathy02.04.01.0010.000533%Not Available
Cerebral arteritis24.05.01.002; 17.08.02.004--Not Available
Cerebral infarction17.08.01.004; 24.04.06.0020.001332%Not Available
Cerebral venous thrombosis24.01.04.005; 17.08.03.0020.000533%Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Cerebrovascular disorder24.03.05.002; 17.08.02.0020.000278%Not Available
Chest pain08.01.08.002; 02.02.02.011; 22.02.08.0030.000533%Not Available
Chest X-ray normal13.19.02.002--Not Available
Chills15.05.03.016; 08.01.09.0010.001066%
Chronic myeloid leukaemia01.10.07.001; 16.01.07.0010.000139%Not Available
Confusional state19.13.01.001; 17.02.03.005--
Cough22.02.03.0010.001332%
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