Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Bleomycin
Drug ID BADD_D00280
Description A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2 (B2 CAS # 9060-10-0). It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors. Bleomycin A2 is used as the representative structure for Bleomycin.
Indications and Usage For palliative treatment in the management malignant neoplasm (trachea, bronchus, lung), squamous cell carcinoma, and lymphomas.
Marketing Status Prescription; Discontinued
ATC Code L01DC01
DrugBank ID DB00290
KEGG ID D07535
MeSH ID D001761
PubChem ID 5460769
NDC Product Code 61703-323; 0143-9240; 0703-3155; 16714-908; 0409-0332; 61703-332; 16714-886; 0143-9241; 70121-1567; 0703-3154; 0409-0323; 69097-364
Synonyms Bleomycin | Bleomycins | BLEO-cell | BLEO cell | BLEOcell | Bleolem | Bléomycine Bellon | Bellon, Bléomycine | Bleomycin A2 | Bleomycin A(2) | Bleomycin B2 | Bleomycin B(2) | Bleomycin Sulfate | Sulfate, Bleomycin | Bleomycinum Mack | Mack, Bleomycinum | Blenoxane | Blanoxan | Bleomicina
Chemical Information
Molecular Formula C55H84N17O21S3+
CAS Registry Number 11056-06-7
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Acute hepatic failure09.01.03.0010.000533%Not Available
Acute myeloid leukaemia16.01.05.001; Available
Acute respiratory distress syndrome22.01.03.0010.000417%
Aggression19.05.01.001--Not Available
Akinesia17.01.02.0030.000533%Not Available
Alveolitis allergic22.01.01.002; Available
Anaphylactic shock10.01.07.002; Available
Arteritis24.05.01.001--Not Available
Asthenia08.01.01.001--Not Available
Bladder pain20.02.02.001--Not Available
Blister23.03.01.001; Available
Body temperature increased13.15.01.001--Not Available
Cardiomyopathy02.04.01.0010.000533%Not Available
Cerebral arteritis24.05.01.002; Available
Cerebral infarction17.08.01.004; Available
Cerebral venous thrombosis24.01.04.005; Available
Cerebrovascular accident24.03.05.001;
Cerebrovascular disorder24.03.05.002; Available
Chest pain08.01.08.002;; Available
Chest X-ray normal13.19.02.002--Not Available
Chronic myeloid leukaemia01.10.07.001; Available
Confusional state19.13.01.001;
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