Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Bleomycin sulfate
Drug ID BADD_D00281
Description A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2 (B2 CAS # 9060-10-0). It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors. Bleomycin A2 is used as the representative structure for Bleomycin.
Indications and Usage For palliative treatment in the management malignant neoplasm (trachea, bronchus, lung), squamous cell carcinoma, and lymphomas.
Marketing Status Prescription; Discontinued
ATC Code L01DC01
DrugBank ID DB00290
KEGG ID D02177
MeSH ID D001761
PubChem ID 72466
TTD Drug ID D06UVD
NDC Product Code 71288-107; 53183-7003; 71288-106; 63323-137; 58623-0033; 63323-136
Synonyms Bleomycin | Bleomycins | BLEO-cell | BLEO cell | BLEOcell | Bleolem | Bléomycine Bellon | Bellon, Bléomycine | Bleomycin A2 | Bleomycin A(2) | Bleomycin B2 | Bleomycin B(2) | Bleomycin Sulfate | Sulfate, Bleomycin | Bleomycinum Mack | Mack, Bleomycinum | Blenoxane | Blanoxan | Bleomicina
Chemical Information
Molecular Formula C55H85N17O25S4
CAS Registry Number 9041-93-4
SMILES CC1=C(N=C(N=C1N)C(CC(=O)N)NCC(C(=O)N)N)C(=O)NC(C(C2=CN=CN2)OC3C(C(C(C(O3)CO)O)O) OC4C(C(C(C(O4)CO)O)OC(=O)N)O)C(=O)NC(C)C(C(C)C(=O)NC(C(C)O)C(=O)NCCC5=NC(=CS5)C6 =NC(=CS6)C(=O)NCCC[S+](C)C)O.OS(=O)(=O)[O-]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Alopecia23.02.02.001--
Blister23.03.01.001; 12.01.06.002--Not Available
Blood glucose decreased13.02.02.001--Not Available
Cerebral arteritis24.05.01.002; 17.08.02.004--Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Chills15.05.03.016; 08.01.09.001--
Confusional state19.13.01.001; 17.02.03.005--
Dyspnoea22.02.01.004; 02.01.03.002--
Erythema23.03.06.001--Not Available
Haemolytic uraemic syndrome01.06.02.001; 20.01.03.011--
Hyperkeratosis23.01.01.001--
Hypotension24.06.03.002--
Interstitial lung disease22.01.02.003; 10.02.01.033--Not Available
Local reaction08.01.03.012--Not Available
Malaise08.01.01.003--
Myocardial infarction02.02.02.007; 24.04.04.009--
Nail disorder23.02.05.002--
Oedema14.05.06.010; 08.01.07.006--Not Available
Pain of skin23.03.03.003--
Paradoxical pressor response24.08.02.003--Not Available
Phlebitis24.05.03.001; 12.02.01.002--
Pneumonitis22.01.01.006--
Pruritus23.03.12.001--
Pulmonary fibrosis22.01.02.006--
Pyrexia08.05.02.003--
Rales22.02.04.004--Not Available
Rash23.03.13.001--Not Available
Raynaud's phenomenon24.04.03.003--Not Available
Scleroderma23.03.02.005; 15.06.01.002; 10.04.07.001--Not Available
Skin hyperpigmentation23.05.01.003--
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