Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Cardiac failure
ADR ID BADD_A00773
ADR Hierarchy
02      Cardiac disorders
02.05      Heart failures
02.05.01      Heart failures NEC
02.05.01.001      Cardiac failure
Description A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION. | Heart failure involving the RIGHT VENTRICLE. | Heart failure caused by dysfunction of the MYOCARDIUM, leading to defective cardiac emptying (contraction) or filling (relaxation). | Heart failure accompanied by EDEMA, such as swelling of the legs and ankles and congestion in the lungs. | Heart failure involving the LEFT VENTRICLE. [MeSH]
MedDRA Code 10007554
MeSH ID D006333; D006333; D006333
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Cardiac failure | Cardiac failure (NOS) | Cardiac failure aggravated | Cardiac failure NOS | Cardiac function failed | Cardiac function failure | Cardiac insufficiency | Decompensation cardiac | Decompensation myocardial | Failure heart | Heart failure | Heart failure (NOS) | Heart failure, unspecified | Heart insufficiency | Heart insuffiency | Insufficiency cardiac | Myocardial decompensation | Decompensated heart failure | Recurrent cardiac decompensation | Hydropic decompensation | Ischemic heart failure | Ischaemic heart failure | Heart Failure | Cardiac Failure | Heart Decompensation | Decompensation, Heart | Heart Failure, Right-Sided | Heart Failure, Right Sided | Right-Sided Heart Failure | Right Sided Heart Failure | Myocardial Failure | Congestive Heart Failure | Heart Failure, Congestive | Heart Failure, Left-Sided | Heart Failure, Left Sided | Left-Sided Heart Failure | Left Sided Heart Failure
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00165Aripiprazole--
BADD_D00169Arsenic trioxide0.000168%
BADD_D00178Atenolol0.000107%
BADD_D00180Atomoxetine0.000348%
BADD_D00193Axitinib0.001757%
BADD_D00194Azacitidine0.002798%
BADD_D00201Azilsartan kamedoxomil0.000039%
BADD_D00214Basiliximab--
BADD_D00230Bendamustine--
BADD_D00231Bendamustine hydrochloride--
BADD_D00254Bepridil--
BADD_D00255Beractant--
BADD_D00263Betaxolol--
BADD_D00269Bexarotene0.000168%
BADD_D00271Bicalutamide0.018560%
BADD_D00272Bicisate dihydrochloride--
BADD_D00277Bisoprolol0.006593%
BADD_D00284Bortezomib0.001310%
BADD_D00285Bosentan0.008027%
BADD_D00286Bosutinib0.002239%
BADD_D00296Brinzolamide0.000468%
BADD_D00299Bromazepam--
BADD_D00304Bromocriptine0.001319%
BADD_D00306Budesonide0.000326%
BADD_D00307Bumetanide0.001045%
BADD_D00318Busulfan0.000168%
BADD_D00328Cabazitaxel--
BADD_D00329Cabergoline--
BADD_D00330Cabozantinib0.002283%
BADD_D00346Candesartan--
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ADReCS-Target
ADR Term Drug Name Target