Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Bexarotene
Drug ID BADD_D00269
Description Bexarotene (Targretin) is an antineoplastic agent indicated by the FDA for Cutaneous T cell lymphoma. It has been used off-label for lung cancer, breast cancer, and Kaposi's sarcoma.
Indications and Usage Used orally for the treatment of skin manifestations of cutaneous T-cell lymphoma (CTCL) in patients who are refractory to at least one prior systemic therapy. Also used topically for the treatment of skin lesions in early (stage IA and IB) CTCL in patients who experience refractory or persistent disease with the use of other therapies or are intolerant of other therapies.
Marketing Status Prescription
ATC Code L01XF03
DrugBank ID DB00307
KEGG ID D03106
MeSH ID D000077610
PubChem ID 82146
NDC Product Code 0832-0285; 67262-0005; 0054-0399; 48943-0013; 68554-0081; 0187-5525; 69238-1250; 68682-003; 11014-0015; 61474-4298; 11014-0435; 54893-0035; 0187-5526; 10888-8105; 11014-0014; 0378-6955; 14096-150; 43975-315; 69988-0006; 0591-2832; 14593-920
Synonyms Bexarotene | 3-methyl-TTNEB | 4-(1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethenyl)benzoic acid | LG69 compound | LGD 1069 | LGD-1069 | LGD1069 | Targretin
Chemical Information
Molecular Formula C24H28O2
CAS Registry Number 153559-49-0
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.0010.001066%Not Available
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.002--
Abnormal faeces07.01.03.001--Not Available
Acne23.02.01.001--Not Available
Adrenal insufficiency14.11.01.004;
Alanine aminotransferase increased13.03.01.003--
Albuminuria20.02.01.001--Not Available
Amylase increased13.05.01.009--
Angina pectoris02.02.02.002;
Arrhythmia02.03.02.001--Not Available
Arthropathy15.01.01.003--Not Available
Aspartate aminotransferase increased13.03.01.006--
Asthenia08.01.01.001--Not Available
Atrial fibrillation02.03.03.0020.000533%
Back pain15.03.04.005--
Blepharitis23.03.04.012; Available
Blood cholesterol increased13.12.01.0020.002131%
Blood creatinine increased13.13.01.0040.000533%
Blood glucose increased13.02.02.0020.000533%Not Available
Blood lactate dehydrogenase increased13.04.02.002--
Blood thromboplastin decreased13.01.02.005--Not Available
Blood thyroid stimulating hormone decreased13.10.03.0110.000533%Not Available
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