Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Brinzolamide
Drug ID BADD_D00296
Description Brinzolamide is a highly specific, non-competitive, reversible carbonic anhydrase inhibitor. Carbonic anhydrase (CA) is an enzyme found in many tissues of the body including the eye. It catalyzes the reversible reaction involving the hydration of carbon dioxide and the dehydration of carbonic acid. In humans, carbonic anhydrase exists as a number of isoenzymes, the most active being carbonic anhydrase II (CA-II). Inhibition of carbonic anhydrase in the ciliary processes of the eye decreases aqueous humor secretion, presumably by slowing the formation of bicarbonate ions with subsequent reduction in sodium and fluid transport. The result is a reduction in intraocular pressure. Brinzolamide is indicated in the treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma.
Indications and Usage For the treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma.
Marketing Status Prescription
ATC Code S01EC04
DrugBank ID DB01194
KEGG ID D00652
MeSH ID C111827
PubChem ID 68844
NDC Product Code 68682-464; 58032-2011; 63629-8793; 58567-101; 0781-6014; 62009-0906; 82019-0001; 40700-0072; 63190-0400; 14445-010; 65727-033; 0078-0722; 62207-011; 0591-2127; 63190-0280; 0065-0275; 68108-0821
Synonyms brinzolamide | (R)-4-(ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno(3,2-E)-1,2-thiazine-6-sulfonamide 1,1-dioxide | Azopt
Chemical Information
Molecular Formula C12H21N3O5S3
CAS Registry Number 138890-62-7
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.0010.003215%Not Available
Abdominal pain07.01.05.0020.003215%
Abdominal pain upper07.01.05.003--
Abnormal sensation in eye06.01.01.001--Not Available
Ageusia17.02.07.001; Available
Angina pectoris24.04.04.002;
Apathy19.04.04.002--Not Available
Arrhythmia02.03.02.001--Not Available
Asthenia08.01.01.0010.006431%Not Available
Asthenopia06.01.01.002--Not Available
Asthma22.03.01.002; Available
Atrial fibrillation02.03.03.0020.002144%
Back pain15.03.04.0050.003215%
Blepharitis23.03.04.012; Available
Blindness17.17.01.003; Available
Blindness transient17.17.01.004; Available
Blood chloride increased13.11.01.005--Not Available
Blood pressure increased13.14.03.005--Not Available
Bradycardia02.03.02.0020.003215%Not Available
Chest discomfort22.02.08.001;; Available
Chest pain22.02.08.003;; Available
Confusional state19.13.01.001;
Conjunctivitis allergic10.01.04.002; Available
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