Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Bicisate dihydrochloride
Drug ID BADD_D00272
Description Bicisate, also known as ethyl cysteinate dimer (ECD), is a N,N'-1,2-ethylene-di-yl-bis-L-cysteinate diethyl ester. It is used in conjunction with technetium Tc99m as a tracer to measure cerebral blood flow with single-photon emission computed tomography (SPECT).[A32374] The complex of bicisate and technetium Tc99m as a kit was developed by Lantheus Medcl and FDA-approved on November 23, 1994.[L2029]
Indications and Usage
Marketing Status Prescription
ATC Code V09AA02
DrugBank ID DB11164
KEGG ID D06029
MeSH ID C059659
PubChem ID 71586979
TTD Drug ID Not Available
NDC Product Code 11994-006; 58272-199; 65044-0010
Synonyms technetium Tc 99m bicisate | 99mTc ethylcysteinate dimer | 99mTc-ECD | Tc-99m-ECD | Tc-99m-bicisate | technetium Tc 99m ethyl cysteine dimer | 99mTc ethyl cysteinate dimer | Tc-99m ECD | Tc-ethyl cysteinate dimer | Neurolite | Tc-99m-L,L-ECD
Chemical Information
Molecular Formula C12H26Cl2N2O4S2
CAS Registry Number 14344-58-2
SMILES CCOC(=O)C(CS)NCCNC(CS)C(=O)OCC.Cl.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Agitation19.06.02.001; 17.02.05.012--
Angina pectoris24.04.04.002; 02.02.02.002--
Anxiety19.06.02.002--
Apnoea22.02.01.001--
Cardiac failure02.05.01.001--
Cyanosis24.03.01.007; 22.02.02.007; 02.01.02.002--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Hallucination19.10.02.002--
Headache17.14.01.001--
Hypertension24.08.02.001--
Malaise08.01.01.003--
Nausea07.01.07.001--
Parosmia22.04.03.007; 17.04.04.002--Not Available
Rash23.03.13.001--Not Available
Seizure17.12.03.001--
Somnolence19.02.05.003; 17.02.04.006--
Syncope24.06.02.012; 17.02.04.008; 02.01.02.008--
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