Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Cell death
ADR ID BADD_A08298
ADR Hierarchy
08      General disorders and administration site conditions
08.03      Tissue disorders NEC
08.03.03      Necrosis NEC
08.03.03.003      Cell death
14      Metabolism and nutrition disorders
14.11      Metabolism disorders NEC
14.11.02      Cell metabolism disorders NEC
14.11.02.005      Cell death
Description The termination of the cell's ability to carry out vital functions such as metabolism, growth, reproduction, responsiveness, and adaptability. [MeSH]
MedDRA Code 10057248
MeSH ID D016923; D001329; D016923
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Cell death | Autolysis | Karyorrhexis | Cytolysis | Cell Death | Death, Cell
ADR Related Proteins
Protein Name UniProt AC TTD Target ID
Abscisic acid-inducible protein kinaseQ02066Not Available
Apoptosis regulator BAXQ07812T89251
Apoptosis regulator Bcl-2P10415T31309
B-cell receptor-associated protein 31P51572Not Available
Bcl2-associated agonist of cell deathQ92934Not Available
C-Jun-amino-terminal kinase-interacting protein 1Q9UQF2T59459
Caspase-3P42574T57943
Caspase-8Q14790T15700
Caspase-9P55211T93903
Cellular tumor antigen p53P04637T15739
Collagen alpha-1(I) chainP02452Not Available
Cyclin-dependent kinase inhibitor 1P38936T39855
D-dopachrome decarboxylaseP30046Not Available
DNA topoisomerase 2-alphaP11388T17048
Glycoprotein hormones alpha chainP01215T16650
GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1P52961Not Available
Granzyme BP10144T08298
Histone-binding protein RBBP7Q16576Not Available
L-dopachrome tautomeraseP40126Not Available
L-lactate dehydrogenase A chainP00338T15053
Macrophage migration inhibitory factorP14174T39977
Mitogen-activated protein kinase 1P28482T58970
Mitogen-activated protein kinase 3P27361T23276
Mitogen-activated protein kinase 8P45983T40097
Mitogen-activated protein kinase 9P49186Not Available
p21 proteinP78460Not Available
Perforin-1P14222Not Available
Peroxiredoxin-2P32119Not Available
Poly [ADP-ribose] polymerase 1Q9ZP54Not Available
Proliferating cell nuclear antigenP12004T21782
RAC-alpha serine/threonine-protein kinaseP31749T67619
Thyroid peroxidaseP07202T51120
Transcription factor JunP05412T69085
Tumor suppressor ARFQ8N726Not Available
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00195Azathioprine--
BADD_D00330Cabozantinib--
BADD_D00356Carbamazepine--
BADD_D00414Ceritinib--
BADD_D00594Deferasirox--
BADD_D00858Everolimus--
BADD_D00948Fluvastatin--
BADD_D00978Fulvestrant--
BADD_D01136Imatinib--
BADD_D01204Isoniazid--
BADD_D01238Lacosamide--
BADD_D01243Lamotrigine--
BADD_D01275Levofloxacin--
BADD_D01401Metformin--
BADD_D01418Methotrexate--
BADD_D01435Methylprednisolone hemisuccinate--
BADD_D01508Mycophenolic acid--
BADD_D01567Nilotinib--
BADD_D01599Olanzapine--
BADD_D01653Paclitaxel--
BADD_D01668Pantoprazole--
BADD_D01687Pazopanib--
BADD_D01909Ramipril--
BADD_D01922Regorafenib--
BADD_D01954Rivaroxaban--
BADD_D01971Rosuvastatin--
BADD_D02100Sunitinib--
BADD_D02105Tacrolimus--
BADD_D02344Vemurafenib--
BADD_D02369Voriconazole--
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