Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Crizotinib
Drug ID BADD_D00535
Description Crizotinib an inhibitor of receptor tyrosine kinase for the treatment of non-small cell lung cancer (NSCLC). Verification of the presence of ALK fusion gene is done by Abbott Molecular's Vysis ALK Break Apart FISH Probe Kit. This verification is used to select for patients suitable for treatment. FDA approved in August 26, 2011.
Indications and Usage Crizotinib is used for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) that is anaplastic-lymphoma kinase (ALK)-positive as detected by a FDA-approved test.
Marketing Status Prescription
ATC Code L01ED01
DrugBank ID DB08865
KEGG ID D09731
MeSH ID D000077547
PubChem ID 11626560
NDC Product Code 0069-8141; 53869-2231; 68724-1020; 0069-8140; 72969-115; 53869-2230
Synonyms Crizotinib | PF-02341066 | PF-2341066 | PF 2341066 | PF2341066 | PF 02341066 | PF02341066 | Xalkori
Chemical Information
Molecular Formula C21H22Cl2FN5O
CAS Registry Number 877399-52-5
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.003--
Abdominal tenderness07.01.05.0040.000533%Not Available
Abnormal faeces07.01.03.0010.000533%Not Available
Abscess11.01.08.0010.000799%Not Available
Acne23.02.01.001--Not Available
Acute hepatic failure09.01.03.001--Not Available
Acute myocardial infarction02.02.02.001; Available
Acute respiratory distress syndrome22.01.03.0010.000417%
Acute respiratory failure22.02.06.001; Available
Ageusia17.02.07.001; Available
Aggression19.05.01.001--Not Available
Alanine aminotransferase increased13.03.01.0030.012521%
Altered state of consciousness19.07.01.003; Available
Alveolitis22.01.01.0010.000278%Not Available
Amaurosis06.02.02.0080.000533%Not Available
Angina pectoris24.04.04.002;
Angioedema23.04.01.001; Available
Ankle fracture15.08.03.005;
Anuria20.01.03.002--Not Available
Arrhythmia02.03.02.001--Not Available
The 1th Page    1 2 3 4 5    Next   Last    Total 20 Pages