Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Isoniazid
Drug ID BADD_D01204
Description Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis.
Indications and Usage For the treatment of all forms of tuberculosis in which organisms are susceptible.
Marketing Status Prescription; Discontinued
ATC Code J04AC01
DrugBank ID DB00951
KEGG ID D00346
MeSH ID D007538
PubChem ID 3767
TTD Drug ID D09XQF
NDC Product Code 71610-108; 50090-1490; 60687-553; 43063-463; 71052-611; 50090-0370; 12785-0002; 50090-0410; 0527-1109; 53002-2920; 71335-0275; 68788-9405; 71610-395; 0555-0071; 46287-009; 63187-978; 12785-0003; 66639-914; 0781-3056; 0555-0066; 70518-0096; 70518-2576; 51079-083
Synonyms Isoniazid | Isonicotinic Acid Hydrazide | Hydrazide, Isonicotinic Acid | Phthivazide | Phthivazid | Isonicotinic Acid Vanillylidenehydrazide | Acid Vanillylidenehydrazide, Isonicotinic | Vanillylidenehydrazide, Isonicotinic Acid | Ftivazide | Tubazide | Isonex
Chemical Information
Molecular Formula C6H7N3O
CAS Registry Number 54-85-3
SMILES C1=CN=CC=C1C(=O)NN
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
HepatotoxicityN-alpha-acetyltransferase 20P61599Not Available3691615; 9922980
HepatotoxicityOmega-amidase NIT2Q9JHW2Not Available26004706
HepatotoxicityGlutathione peroxidase 1P04041Not Available26004706
HepatotoxicityAlanine aminotransferase 1P24298Not Available4000989; 707874; 110184
HepatotoxicityN-alpha-acetyltransferase 20P61599Not AvailableNot Available
HepatotoxicityAlbuminP02770Not Available26004706
HepatotoxicityCatalaseP04762Not Available26004706
Systemic lupus erythematosusN-alpha-acetyltransferase 20P61599Not AvailableNot Available
Systemic lupus erythematosusN-alpha-acetyltransferase 20P61599Not Available3691615; 9922980
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal distension07.01.04.0010.019111%
Abdominal pain07.01.05.0020.082814%
Abdominal pain upper07.01.05.003--
Abscess11.01.08.0010.019111%Not Available
Acidosis14.01.03.0020.019111%
Acidosis hyperchloraemic14.01.01.0070.012741%Not Available
Activated partial thromboplastin time prolonged13.01.02.0010.012741%
Acute hepatic failure09.01.03.0010.048192%Not Available
Acute psychosis19.03.01.0010.012741%Not Available
Acute respiratory distress syndrome22.01.03.0010.008309%
Agitation19.06.02.001; 17.02.05.012--
Agranulocytosis01.02.03.001--Not Available
Alanine aminotransferase increased13.03.01.0030.108295%
Alopecia23.02.02.001--
Altered state of consciousness19.07.01.003; 17.02.04.0010.057332%Not Available
Alveolitis22.01.01.0010.012741%Not Available
Ammonia increased13.03.01.0230.012741%Not Available
Anaemia01.03.02.001--
Anaphylactic reaction24.06.03.006; 10.01.07.0010.031851%
Angioedema23.04.01.001; 10.01.05.0090.038222%Not Available
Aortic aneurysm24.02.03.0010.012741%Not Available
Aplasia pure red cell01.03.03.001; 10.02.01.0030.025481%Not Available
Aplastic anaemia01.03.03.002--Not Available
Arthralgia15.01.02.0010.050962%
Ascites09.01.05.003; 07.07.01.001; 02.05.04.0020.044592%
Aspartate aminotransferase increased13.03.01.0060.101924%
Asthenia08.01.01.0010.095554%Not Available
Ataxia17.02.02.001; 08.01.02.0040.019111%
Atrophy08.03.04.001--Not Available
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