Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ketoprofen
Drug ID BADD_D01231
Description Ketoprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties.
Indications and Usage For symptomatic treatment of acute and chronic rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, primary dysmenorrhea and mild to moderate pain associated with musculotendinous trauma (sprains and strains), postoperative (including dental surgery) or postpartum pain.
Marketing Status Prescription; Discontinued
ATC Code M01AE03; M02AA10
DrugBank ID DB01009
KEGG ID D00132
MeSH ID D007660
PubChem ID 3825
TTD Drug ID D0W9WF
NDC Product Code 49452-3917; 68981-031; 82348-102; 0276-0504; 12660-0006; 69336-127; 12854-516; 43235-0010; 63275-9996; 51927-0057; 76465-0001; 51927-0025; 51552-0307; 63187-018; 38779-0078; 51927-0231; 0395-8056; 45865-485; 38779-3039; 49452-3924; 0378-8200; 79572-019; 51604-0011
Synonyms Ketoprofen | Benzoylhydratropic Acid | 2-(3-Benzoylphenyl)propionic Acid | Profenid | Alrheumum | Orudis | 19,583 RP | RP, 19,583 | RP-19583 | RP 19583 | RP19583 | Alrheumat
Chemical Information
Molecular Formula C16H14O3
CAS Registry Number 22071-15-4
SMILES CC(C1=CC(=CC=C1)C(=O)C2=CC=CC=C2)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Gastrointestinal toxicityGlutathione reductase, mitochondrialP00390T3080311991627; 11131303; 11930903; 11230998
Gastrointestinal toxicityTumor necrosis factorP01375T2017811991627; 11131303; 11930903; 11230998
Toxic dilatation of intestineGlutathione reductase, mitochondrialP00390T3080311991627; 11131303; 11930903; 11230998
Toxic dilatation of intestineTumor necrosis factorP01375T2017811991627; 11131303; 11930903; 11230998
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.0020.033111%
Abdominal pain upper07.01.05.0030.066223%
Acne23.02.01.0010.008278%Not Available
Affective disorder19.04.04.001--Not Available
Agitation19.06.02.001; 17.02.05.012--
Agranulocytosis01.02.03.0010.008278%Not Available
Alopecia23.02.02.001--
Amnesia19.20.01.001; 17.03.02.001--
Anaemia01.03.02.0010.041389%
Anaphylactic reaction10.01.07.001; 24.06.03.0060.045528%
Anaphylactic shock24.06.02.004; 10.01.07.0020.011877%Not Available
Angioedema23.04.01.001; 10.01.05.0090.173835%Not Available
Anxiety19.06.02.002--
Aphasia19.21.01.001; 17.02.03.0010.008278%
Aplastic anaemia01.03.03.002--Not Available
Arrhythmia02.03.02.001--Not Available
Arthralgia15.01.02.001--
Asthenia08.01.01.001--Not Available
Asthma22.03.01.002; 10.01.03.010--Not Available
Back pain15.03.04.0050.016556%
Blood pressure decreased13.14.03.0020.008278%Not Available
Blood pressure increased13.14.03.0050.008278%Not Available
Blood urea increased13.13.01.006--Not Available
Bronchospasm22.03.01.004; 10.01.03.0120.020695%
Cardiac arrest02.03.04.0010.008278%
Cardiac failure02.05.01.0010.003239%
Cardiac failure congestive02.05.01.002--Not Available
Cardio-respiratory arrest22.02.06.007; 02.03.04.0020.004319%Not Available
Cardiogenic shock24.06.02.006; 02.05.01.0030.002159%Not Available
Cellulitis23.09.01.001; 11.02.01.0010.012417%Not Available
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