Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Furosemide
Drug ID BADD_D00979
Description Furosemide is a potent loop diuretic that acts on the kidneys to ultimately increase water loss from the body. It is an anthranilic acid derivative.[L7958] Furosemide is used for edema secondary to various clinical conditions, such as congestive heart failure exacerbation, liver failure, renal failure, and high blood pressure.[L7961] It mainly works by inhibiting electrolyte reabsorption from the kidneys and enhancing the excretion of water from the body. Furosemide has a fast onset and short duration of action and has been used safely and effectively in both pediatric and adult patients.[A182495] The use of furosemide is particularly beneficial in clinical settings that require a drug with a higher diuretic potential. In addition to oral formulations, the solution for intravenous and intramuscular administration is also available, which is typically limited to patients who are unable to take oral medication or for patients in emergency clinical situations.[L7958]
Indications and Usage For the treatment of edema associated with congestive heart failure, cirrhosis of the liver, and renal disease, including the nephrotic syndrome. Also for the treatment of hypertension alone or in combination with other antihypertensive agents.
Marketing Status Prescription; Discontinued
ATC Code C03CA01
DrugBank ID DB00695
KEGG ID D00331
MeSH ID D005665
PubChem ID 3440
TTD Drug ID D0PQ3G
NDC Product Code 43353-018; 12634-416; 68083-432; 30698-066; 51662-1226; 61919-242; 0404-9864; 68071-3273; 0054-3298; 68071-4349; 66432-550; 55154-5539; 0404-9863; 0615-7938; 68788-6948; 0054-8301; 60760-708; 0904-7177; 43063-702; 70193-0002; 0378-0216; 30698-067; 0615-7937; 63187-097; 0054-4299; 71288-203; 57451-0006; 71335-0129; 70121-1164; 0615-8368; 42708-123; 51927-1784; 36000-283; 16729-500; 51407-115; 52584-052; 0054-4297; 68083-433; 63323-280; 71052-238; 70121-1163; 68083-434; 43353-341; 71872-7278; 0409-9631; 48087-0054; 52584-283; 25021-311; 66432-549; 55154-5540; 71610-096; 72789-032; 70121-1076; 36000-065; 0054-4301; 68071-4022; 55154-2365; 0904-7178; 0054-8299; 70529-550; 49452-3222; 63187-437; 70518-3061; 36000-282; 58118-0143; 50090-5702; 68071-4445; 42291-468; 0404-9861; 57451-0007; 63187-517; 55154-9582; 43063-716; 0615-8369; 51662-1336; 71610-635; 63629-1215; 71872-7277; 63629-8057; 51662-1575; 68071-1708; 12634-533; 50090-5706; 0378-0232; 53002-4300; 71335-1683; 0054-8297; 23155-473; 68071-2461; 68788-7354; 0409-6102; 42291-470; 71872-7059; 63629-1119; 70518-0836; 17337-0087; 60432-613; 70934-111; 43547-401; 42291-469; 72789-033; 71335-0384; 51662-1227; 68094-756; 70518-0050; 71335-0601; 68071-2360; 55700-461; 72789-157; 55150-323; 63629-1216; 55154-2364; 51927-0078; 68071-1809; 70518-2766; 63629-1217; 67296-1665; 60760-707; 68071-4522; 71335-0842; 0409-1639; 53808-1109; 51662-1572; 71610-634; 70860-302; 43353-220; 50090-5429; 71610-284; 82348-105; 70518-0251; 71610-049; 50090-3455; 43353-221; 69315-116; 36000-063; 50090-2951; 0615-8370; 72789-030; 63629-1214; 55150-322; 63629-1120; 71610-309; 55154-4452; 63187-790; 70518-0809; 71335-0397; 43063-849; 0378-0208; 43353-747; 50090-3313; 51927-0077; 71610-636; 71872-7127; 68071-4534; 51407-114; 36000-284; 63187-506; 61919-442; 63629-1435; 50090-2713; 50090-4111; 68788-7265; 51552-0940; 30698-060; 68071-2325; 43063-806; 68071-2313; 51662-1574; 66326-401; 43547-402; 71872-7236; 50090-4109; 63187-739; 36000-064; 16729-501; 48087-0053; 16729-502; 51079-073; 50090-3338; 0404-9862; 71335-1632; 50090-0150; 50090-3488; 64679-759; 51407-113; 70529-062; 51079-072; 43547-403; 52584-322; 0054-3294; 68094-867; 81565-201; 63415-0025; 55700-452; 71610-305; 72166-003; 60760-217; 51079-527; 55154-9581; 70529-061; 43353-069; 71610-308; 0615-7957; 55150-324; 68788-6784; 67296-1547; 50090-2560; 67296-0691; 50090-3339; 63629-8058; 71335-0852; 69315-118; 52584-284; 69315-117; 68071-3194; 70529-549
Synonyms Furosemide | Frusemide | Fursemide | Frusemid | Fusid | Lasix | Furosemide Monohydrochloride | Errolon | Furanthril | Furantral | Furosemide Monosodium Salt
Chemical Information
Molecular Formula C12H11ClN2O5S
CAS Registry Number 54-31-9
SMILES C1=COC(=C1)CNC2=CC(=C(C=C2C(=O)O)S(=O)(=O)N)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
HyperparathyroidismParathyroid hormone/parathyroid hormone-related peptide receptorQ03431T677106637931; 2809941
Renal failureVery low-density lipoprotein receptorP98155Not Available6624545; 190608; 227218; 8740580; 189577; 211802; 6941788; 6586074; 8139482
Renal failureLipoprotein lipaseP06858T286926624545; 190608; 227218; 8740580; 189577; 211802; 6941788; 6586074; 8139482
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal distension07.01.04.0010.000317%
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.003--
Abscess11.01.08.0010.000063%Not Available
Acidosis14.01.03.0020.000066%
Activated partial thromboplastin time prolonged13.01.02.0010.000095%
Acute febrile neutrophilic dermatosis23.03.03.033; 01.02.01.0060.000158%Not Available
Acute hepatic failure09.01.03.001--Not Available
Acute myocardial infarction24.04.04.001; 02.02.02.001--Not Available
Acute prerenal failure20.01.03.001; 24.06.02.0030.000095%Not Available
Acute pulmonary oedema22.01.03.005; 02.05.02.0040.000412%Not Available
Acute respiratory distress syndrome22.01.03.0010.000033%
Acute respiratory failure22.02.06.001; 14.01.04.0040.000132%Not Available
Agitation19.06.02.001; 17.02.05.012--
Agranulocytosis01.02.03.001--Not Available
Alanine aminotransferase increased13.03.01.003--
Alkalosis hypochloraemic14.01.02.0030.000158%Not Available
Alopecia23.02.02.001--
Altered state of consciousness19.07.01.003; 17.02.04.0010.000285%Not Available
Anaemia01.03.02.0010.001901%
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Anaphylactic shock10.01.07.002; 24.06.02.0040.000158%Not Available
Anaphylactoid reaction24.06.03.007; 10.01.07.0030.000063%Not Available
Angina pectoris24.04.04.002; 02.02.02.0020.000158%
Angioedema10.01.05.009; 23.04.01.0010.000444%Not Available
Anion gap increased13.02.01.0140.000095%Not Available
Ankle fracture15.08.03.005; 12.04.01.0050.000063%
Anticholinergic syndrome17.05.01.0010.000025%Not Available
Anuria20.01.03.0020.000285%Not Available
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