Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Everolimus
Drug ID BADD_D00858
Description Everolimus is a derivative of Rapamycin (sirolimus), and works similarly to Rapamycin as an mTOR (mammalian target of rapamycin) inhibitor. It is currently used as an immunosuppressant to prevent rejection of organ transplants. In a similar fashion to other mTOR inhibitors Everolimus' effect is solely on the mTORC1 protein and not on the mTORC2 protein.
Indications and Usage Indicated in pediatric and adult patients with tuberous sclerosis complex (TSC) for the treatment of subependymal giant cell astrocytoma (SEGA) that requires therapeutic intervention but cannot be curatively resected.
Marketing Status Prescription
ATC Code L01EG02; L04AA18
DrugBank ID DB01590
KEGG ID D02714
MeSH ID D000068338
PubChem ID 6442177
TTD Drug ID D0K3QS
NDC Product Code 65727-064; 65129-1324; 0078-0626; 0078-0620; 0054-0482; 67877-719; 52076-6247; 0078-0594; 0054-0470; 49884-159; 0378-3097; 49884-158; 68254-6234; 65727-063; 49884-160; 70377-013; 71796-012; 49884-119; 0378-3098; 70225-1103; 52076-6253; 70377-010; 0078-0422; 0054-0497; 0078-0414; 0054-0471; 0378-0006; 0093-7767; 0078-0627; 52076-6234; 62227-013; 0093-7766; 0078-0628; 71052-559; 67877-720; 0378-0005; 65727-046; 49884-125; 0054-0472; 0054-0604; 0078-0566; 49884-283; 0378-0007; 67877-721; 67877-718; 51991-823; 0054-0481; 17404-1027; 0078-0417; 0078-0415; 0093-7768; 49884-127; 70377-011; 62227-018; 70377-012; 0054-0480; 62227-019; 51991-821; 51991-822; 0078-0567; 0378-3096; 51991-824
Synonyms Everolimus | SDZ RAD | RAD, SDZ | SDZ-RAD | 40-O-(2-hydroxyethyl)-rapamycin | RAD 001 | 001, RAD | RAD001 | Certican | Afinitor
Chemical Information
Molecular Formula C53H83NO14
CAS Registry Number 159351-69-6
SMILES CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O) C(C)CC4CCC(C(C4)OC)OCCO)C)C)O)OC)C)C)C)OC
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal distension07.01.04.0010.010583%
Abdominal pain07.01.05.0020.034667%
Abdominal pain lower07.01.05.010--Not Available
Abdominal pain upper07.01.05.0030.025909%
Abnormal faeces07.01.03.0010.001825%Not Available
Abscess11.01.08.0010.003649%Not Available
Acidosis14.01.03.002--
Acne23.02.01.0010.023355%Not Available
Activated partial thromboplastin time prolonged13.01.02.001--
Acute hepatic failure09.01.03.001--Not Available
Acute myeloid leukaemia16.01.05.001; 01.10.05.001--Not Available
Acute myocardial infarction24.04.04.001; 02.02.02.001--Not Available
Acute pulmonary oedema02.05.02.004; 22.01.03.0050.000730%Not Available
Acute respiratory distress syndrome22.01.03.0010.000666%
Acute respiratory failure22.02.06.001; 14.01.04.0040.000666%Not Available
Adrenal disorder05.01.03.0010.000730%Not Available
Adrenal insufficiency14.11.01.004; 05.01.02.0010.000730%
Ageusia07.14.03.003; 17.02.07.0010.007663%Not Available
Aggression19.05.01.001--Not Available
Agitation19.06.02.001; 17.02.05.012--
Alanine aminotransferase increased13.03.01.0030.011677%
Alopecia23.02.02.001--
Altered state of consciousness19.07.01.003; 17.02.04.001--Not Available
Alveolar proteinosis22.01.02.009--Not Available
Alveolitis22.01.01.001--Not Available
Alveolitis allergic10.01.03.008; 22.01.01.0020.000190%Not Available
Amenorrhoea21.01.02.001; 05.05.01.002--
Amnesia19.20.01.001; 17.03.02.001--
Anaemia01.03.02.0010.062765%
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