Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Liver injury
ADR ID BADD_A06414
ADR Hierarchy
09      Hepatobiliary disorders
09.01      Hepatic and hepatobiliary disorders
09.01.07      Hepatocellular damage and hepatitis NEC
09.01.07.022      Liver injury
12      Injury, poisoning and procedural complications
12.01      Injuries NEC
12.01.02      Abdominal injuries NEC
12.01.02.003      Liver injury
Description Not Available
MedDRA Code 10067125
MeSH ID Not Available
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Acute liver damage | Damage liver | Hepatic damage | Hepatic damage (NOS) | Injury to liver | Liver damage | Liver damage aggravated | Liver injury | Acute liver injury | Chronic liver injury | Metabolic liver injury
ADR Related Proteins
Protein Name UniProt AC TTD Target ID
Alanine aminotransferase 1P24298Not Available
Alanine aminotransferase 1Q8QZR5Not Available
Alpha-2A adrenergic receptorP08913T11448
Arylamine N-acetyltransferase 2P11245Not Available
Bile salt export pumpO95342T33969
C-C chemokine receptor type 4P51679T06955
C-C chemokine receptor type 9P51686T97873
C-C motif chemokine 2P10148Not Available
C-X-C chemokine receptor type 3P49682T25315
Cytochrome P450Q80XK1Not Available
Glyceraldehyde-3-phosphate dehydrogenaseP04406T39321
Insulin receptor substrate 1P35568T15510
Insulin receptor substrate 2Q9Y4H2T06128
Intercellular adhesion molecule 1P05362T26203
Interleukin-10P18893Not Available
Interleukin-6P08505Not Available
Lysosome-associated membrane glycoprotein 1P11279T31145
Methylenetetrahydrofolate reductaseQ9WU20Not Available
Mitogen-activated protein kinase 1P28482T58970
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alphaO00443Not Available
Proliferating cell nuclear antigenQ00268Not Available
Tumor necrosis factorP06804Not Available
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D000054-oxo-3-(3-oxo-1-phenylbutyl)chromen-2-olate--
BADD_D00014Abiraterone--
BADD_D00018Acarbose--
BADD_D00022Acenocoumarol--
BADD_D00023Acetaminophen--
BADD_D00047Afatinib--
BADD_D00069Alfuzosin--
BADD_D00076Allopurinol--
BADD_D00085Alprazolam--
BADD_D00100Ambrisentan--
BADD_D00103Amikacin--
BADD_D00107Aminoglutethimide--
BADD_D00115Amiodarone--
BADD_D00116Amiodarone hydrochloride--
BADD_D00126Amobarbital--
BADD_D00129Amoxicillin--
BADD_D00132Amphotericin b--
BADD_D00151Apixaban--
BADD_D00156Apremilast--
BADD_D00165Aripiprazole--
BADD_D00172Asenapine--
BADD_D00176Atazanavir--
BADD_D00180Atomoxetine--
BADD_D00195Azathioprine--
BADD_D00203Azithromycin--
BADD_D00210Balsalazide--
BADD_D00269Bexarotene--
BADD_D00271Bicalutamide--
BADD_D00285Bosentan--
BADD_D00286Bosutinib--
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