Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Amikacin
Drug ID BADD_D00103
Description Amikacin is a semi-synthetic aminoglycoside antibiotic that is derived from kanamycin A.[FDA label] Amikacin is synthesized by acylation with the l-(-)-γ-amino-α-hydroxybutyryl side chain at the C-1 amino group of the deoxystreptamine moiety of kanamycin A.[A39531] Amikacin's unique property is that it exerts activity against more resistant gram-negative bacilli such as Acinetobacter baumanii and Pseudomonas aeruginosa. Amikacin also exerts excellent activity against most aerobic gram-negative bacilli from the Enterobacteriaceae family, including Nocardia and some Mycobacterium (M. avium-intracellulare, M. chelonae, and M. fortuitum)[L4680]. M. avium-intracellulare (MAC) is a type of nontuberculous mycobacteria (NTM) found in water and soil. Symptoms of this disease include a persistent cough, fatigue, weight loss, night sweats, and shortness of breath and the coughing up of blood.[L4680] Several forms of amikacin are used currently, including an intravenous (IV) or intramuscular (IM) injection.[F1949] In September 2018, a liposomal inhalation suspension of this drug was approved by the FDA for the treatment of lung disease caused by Mycobacterium avium complex (MAC) bacteria in a small population of patients with the disease who do not respond to traditional treatment.[L4680,L4681]
Indications and Usage For short-term treatment of serious infections due to susceptible strains of Gram-negative bacteria, including Pseudomonas species, Escherichia coli, species of indole-positive and indole-negative Proteus, Providencia species, Klebsiella-Enterobacter-Serratia species, and Acinetobacter (Mima-Herellea) species. Amikacin may also be used to treat Mycobacterium avium and Mycobacterium tuberculosis infections.
Marketing Status Prescription; Discontinued
ATC Code D06AX12; J01GB06; S01AA21
DrugBank ID DB00479
KEGG ID D02543
MeSH ID D000583
PubChem ID 37768
TTD Drug ID D0Y3MO
NDC Product Code 71558-590
Synonyms Amikacin | Yectamid | Amikacina Medical | Medical, Amikacina | Amikacina Normon | Normon, Amikacina | Amikafur | Amikalem | Amikason's | Amikayect | Amikin | Biklin | Biclin | Amiklin | Amukin | BB-K8 | BB K8 | BBK8 | BB-K 8 | BB K 8 | BBK 8 | Gamikal | Kanbine | Oprad | A.M.K | Amikacin Sulfate | Sulfate, Amikacin
Chemical Information
Molecular Formula C22H43N5O13
CAS Registry Number 37517-28-5
SMILES C1C(C(C(C(C1NC(=O)C(CCN)O)OC2C(C(C(C(O2)CO)O)N)O)O)OC3C(C(C(C(O3)CN)O)O)O)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Toxicity to various agents1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1Q9NQ66T26846Not Available
Toxicity to various agentsPhospholipase A2P04054T31479Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain upper07.01.05.003--
Acute hepatic failure09.01.03.0010.000371%Not Available
Albuminuria20.02.01.001--Not Available
Alveolitis allergic22.01.01.002; 10.01.03.0080.000557%Not Available
Anaemia01.03.02.001--
Anxiety19.06.02.002--
Aphonia22.02.05.024; 19.19.01.002; 17.02.08.0090.004642%
Apnoea22.02.01.001--
Arthralgia15.01.02.001--
Arthritis15.01.01.0010.000371%
Asthenia08.01.01.0010.001671%Not Available
Asthma22.03.01.002; 10.01.03.0100.000557%Not Available
Azotaemia20.01.01.001--Not Available
Back pain15.03.04.005--
Blindness17.17.01.003; 06.02.02.001--Not Available
Blood creatinine increased13.13.01.0040.000557%
Blood pressure increased13.14.03.0050.000371%Not Available
Body temperature increased13.15.01.001--Not Available
Bronchospasm10.01.03.012; 22.03.01.0040.001671%
Chest discomfort22.02.08.001; 08.01.08.019; 02.02.02.0090.001485%Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.0110.001114%Not Available
Cough22.02.03.0010.010026%
Deafness04.02.01.0010.001017%Not Available
Deafness neurosensory17.04.07.001; 04.02.01.0020.000743%Not Available
Death08.04.01.0010.001356%
Dehydration14.05.05.0010.000557%
Depression19.15.01.001--
Dermatitis23.03.04.002--Not Available
Diarrhoea07.02.01.0010.002971%
Dizziness17.02.05.003; 02.01.02.004; 24.06.02.0070.002599%
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