Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Sjogren's syndrome
ADR ID BADD_A04010
ADR Hierarchy
06      Eye disorders
06.08      Eye disorders NEC
06.08.02      Lacrimation disorders
06.08.02.011      Sjogren's syndrome
07      Gastrointestinal disorders
07.06      Salivary gland conditions
07.06.01      Oral dryness and saliva altered
07.06.01.010      Sjogren's syndrome
10      Immune system disorders
10.04      Autoimmune disorders
10.04.04      Autoimmune disorders NEC
10.04.04.009      Sjogren's syndrome
15      Musculoskeletal and connective tissue disorders
15.06      Connective tissue disorders (excl congenital)
15.06.01      Connective tissue disorders NEC
15.06.01.015      Sjogren's syndrome
Description Chronic inflammatory and autoimmune disease in which the salivary and lacrimal glands undergo progressive destruction by lymphocytes and plasma cells resulting in decreased production of saliva and tears. The primary form, often called sicca syndrome, involves both KERATOCONJUNCTIVITIS SICCA and XEROSTOMIA. The secondary form includes, in addition, the presence of a connective tissue disease, usually rheumatoid arthritis. [MeSH]
MedDRA Code 10040767
MeSH ID D012859
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Gougerot-Mulock-Houwer syndrome | Sicca syndrome | Sjogren's | Sjogren's disease | Sjogren's syndrome | Syndrome sicca | Syndrome Sjogren's | Sjoegren's syndrome | Sjogren's Syndrome | Sjogrens Syndrome | Syndrome, Sjogren's | Sjogren Syndrome | Sicca Syndrome | Syndrome, Sicca
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00056Albuterol0.000006%
BADD_D00066Alendronic acid0.000176%
BADD_D00100Ambrisentan0.000265%
BADD_D00142Anastrozole0.001589%
BADD_D00203Azithromycin0.000006%
BADD_D00277Bisoprolol0.000314%
BADD_D00293Brexpiprazole0.000131%
BADD_D00356Carbamazepine0.000186%
BADD_D00471Ciprofloxacin--
BADD_D00504Clopidogrel0.000064%
BADD_D00551Cyclosporine0.000111%
BADD_D00680Dimethyl fumarate0.001560%
BADD_D00735Duloxetine hydrochloride--
BADD_D00856Etoricoxib--
BADD_D00864Ezetimibe0.000471%
BADD_D00898Finasteride0.000045%
BADD_D01103Hydroxychloroquine0.002789%
BADD_D01231Ketoprofen--
BADD_D01251Latanoprost0.000067%
BADD_D01252Leflunomide0.001157%
BADD_D01257Letrozole0.001054%
BADD_D01281Levonorgestrel0.001418%
BADD_D01285Levothyroxine0.000010%
BADD_D01290Lifitegrast0.001002%
BADD_D01418Methotrexate0.000625%
BADD_D01496Montelukast0.000015%
BADD_D01567Nilotinib0.000112%
BADD_D01592Obeticholic acid0.001042%
BADD_D01687Pazopanib0.000112%
BADD_D01831Prednisolone0.000070%
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