Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Levonorgestrel
Drug ID BADD_D01281
Description Levonorgestrel (LNG) is a synthetic progestogen similar to [Progesterone] used in contraception and hormone therapy.[A181988,T659] Also known as Plan B, it is used as a single agent in emergency contraception, and as a hormonal contraceptive released from an intrauterine device, commonly referred to as an IUD. Some of these devices are known as Jaydess, Kyleena, and Mirena. A subdermal implant of levonorgestrel that slowly releases the hormone over a long-term period is also available.[L7823] In addition to the above uses, levonorgestrel is used as a component of long-term combination contraceptives.[A181991,L7760,L7778] Globally, levonorgestrel is the most commonly used emergency contraceptive. It was initially granted FDA approval in 1982 and was the first emergency contraceptive containing only progesterone, showing high levels of efficacy and a lack of estrogenic adverse effects when compared to older emergency contraceptive regimens.[A181976,A181994,L7760]
Indications and Usage For the treatment of menopausal and postmenopausal disorders and alone or in combination with other hormones as an oral contraceptive.
Marketing Status Prescription; OTC; Discontinued
ATC Code G03AC03; G03AD01
DrugBank ID DB00367
KEGG ID D00950
MeSH ID D016912
PubChem ID 13109
TTD Drug ID D0BA9U
NDC Product Code 50419-424; 73302-911; 22552-0047; 43386-622; 45541-1244; 51660-723; 12866-1010; 50419-422; 63190-0660; 63190-0130; 45541-1174; 65129-2003; 50090-1141; 62756-720; 58602-721; 16714-809; 50419-423; 66499-0018; 69536-162; 69536-146; 40032-622; 71205-361; 57297-852; 0113-2003; 65089-0036; 68071-4247; 58602-712; 0536-1142; 68071-4294; 64122-605; 44132-004; 50090-3830; 68180-853; 69536-200; 51508-012; 69536-103; 58602-841; 59057-002; 53104-7669; 62756-718; 62756-723; 69953-515; 68180-852; 70700-164; 69536-133; 71205-120; 59057-001; 50102-211; 0023-5858; 69953-616; 63190-0850; 68071-4126; 44132-012
Synonyms Levonorgestrel | l-Norgestrel | l Norgestrel | 18,19-dinorpregn-4-en-20-yn-3-one, 13-ethyl-17-hydroxy-, (17alpha)-(-)- | D-Norgestrel | D Norgestrel | Microval | duofem | Microlut | Mirena | Norgeston | Norplant-2 | Norplant 2 | Norplant2 | NorLevo | Norplant | Plan B | Vikela | Cerazet | Capronor
Chemical Information
Molecular Formula C21H28O2
CAS Registry Number 797-63-7
SMILES CCC12CCC3C(C1CCC2(C#C)O)CCC4=CC(=O)CCC34
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal adhesions12.02.03.006; 07.07.03.0010.020845%Not Available
Abdominal discomfort07.01.06.001--Not Available
Abdominal distension07.01.04.0010.234507%
Abdominal pain07.01.05.0021.226735%
Abdominal pain lower07.01.05.0101.886483%Not Available
Abdominal pain upper07.01.05.003--
Abdominal rigidity07.01.05.0110.004169%Not Available
Abdominal tenderness07.01.05.0040.020845%Not Available
Abnormal weight gain14.03.02.0100.015634%Not Available
Abortion18.01.01.0010.008338%Not Available
Abortion incomplete18.01.01.003--Not Available
Abortion missed18.01.01.0020.015634%Not Available
Abortion spontaneous18.01.04.0010.270986%Not Available
Abscess11.01.08.001--Not Available
Acne23.02.01.0010.258479%Not Available
Acne cystic23.02.01.0050.010423%Not Available
Acne pustular23.02.01.007; 11.01.12.0160.002085%Not Available
Acute abdomen07.01.06.0150.010423%Not Available
Acute myocardial infarction24.04.04.001; 02.02.02.001--Not Available
Acute promyelocytic leukaemia16.01.05.003; 01.10.05.0030.002085%Not Available
Acute pulmonary oedema22.01.03.005; 02.05.02.004--Not Available
Adenoma benign16.02.02.0010.002085%Not Available
Affective disorder19.04.04.0010.041690%Not Available
Ageusia17.02.07.001; 07.14.03.003--Not Available
Aggression19.05.01.0010.055240%Not Available
Agitation17.02.05.012; 19.06.02.001--
Agoraphobia19.06.03.0040.002085%Not Available
Agranulocytosis01.02.03.001--Not Available
Alanine aminotransferase increased13.03.01.003--
Alopecia23.02.02.0010.333522%
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