Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Latanoprost
Drug ID BADD_D01251
Description Latanoprost is a prodrug analog of prostaglandin F2 alpha that is used to treat elevated intraocular pressure (IOP). It was initially approved by the FDA in 1998. Latanoprost is the first topical prostaglandin F2 alpha analog used for glaucoma treatment.[A184493] It has been found to be well-tolerated and its use does not normally result in systemic adverse effects like other drugs used to treat elevated intraocular pressure, such as [Timolol]. Another benefit latanoprost is that it can be administered once a day.[A184490]
Indications and Usage For the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension.
Marketing Status Prescription; Discontinued
ATC Code S01EE01
DrugBank ID DB00654
KEGG ID D00356
MeSH ID D000077338
PubChem ID 5311221
TTD Drug ID D0C6NM
NDC Product Code 90027-006; 68071-2376; 59762-0333; 47335-317; 24208-463; 63190-0710; 65326-004; 45542-1156; 0009-5172; 51927-4864; 42385-039; 55545-0462; 71684-0547; 45542-1159; 68071-4893; 12079-0475; 64980-516; 50090-1920; 61314-547; 51927-0091; 68245-0002; 71205-154; 65035-128; 51552-1385; 17478-625; 46144-156; 65862-872; 40016-001; 71052-041; 61919-112; 65727-026; 61556-050; 65427-007; 81997-001; 68071-4650; 51927-0090; 24002-0018; 54893-0010; 10695-048; 0013-8303; 82231-111; 68071-4612; 70069-421
Synonyms Latanoprost | PhXA34 | PHXA41 | Xalatan
Chemical Information
Molecular Formula C26H40O5
CAS Registry Number 130209-82-4
SMILES CC(C)OC(=O)CCCC=CCC1C(CC(C1CCC(CCC2=CC=CC=C2)O)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Abnormal sensation in eye06.01.01.0010.000338%Not Available
Acne23.02.01.0010.000225%Not Available
Ageusia17.02.07.001; 07.14.03.0030.000338%Not Available
Alopecia23.02.02.001--
Amnesia17.03.02.001; 19.20.01.001--
Anaphylactic shock24.06.02.004; 10.01.07.0020.000225%Not Available
Angina pectoris24.04.04.002; 02.02.02.002--
Angioedema23.04.01.001; 10.01.05.009--Not Available
Anosmia22.04.03.006; 17.04.04.0010.000901%
Anxiety19.06.02.002--
Arrhythmia02.03.02.0010.000563%Not Available
Arthralgia15.01.02.001--
Arthritis15.01.01.0010.000901%
Arthropathy15.01.01.0030.001126%Not Available
Asthenia08.01.01.001--Not Available
Asthenopia06.01.01.0020.000225%Not Available
Asthma22.03.01.002; 10.01.03.0100.001126%Not Available
Atrial fibrillation02.03.03.002--
Atrioventricular block second degree02.03.01.0050.000450%
Back disorder15.03.01.0140.000225%Not Available
Back pain15.03.04.005--
Blepharal pigmentation23.05.01.009; 06.06.04.0140.000225%Not Available
Blepharitis23.03.04.012; 06.04.04.001--Not Available
Blepharospasm06.05.01.001; 17.17.02.0010.000225%Not Available
Blindness17.17.01.003; 06.02.02.0010.001576%Not Available
Blindness unilateral17.17.01.016; 06.02.02.0090.000901%Not Available
Blister23.03.01.001; 12.01.06.0020.000338%Not Available
Blood pressure fluctuation24.06.01.0020.000338%Not Available
Blood pressure increased13.14.03.005--Not Available
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