Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Pazopanib
Drug ID BADD_D01687
Description Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009.
Indications and Usage Treatment of advanced renal cell cancer and advanced soft tissue sarcoma (in patients previously treated with chemotherapy)
Marketing Status approved
ATC Code L01EX03
DrugBank ID DB06589
KEGG ID D05380
MeSH ID C516667
PubChem ID 10113978
TTD Drug ID Not Available
NDC Product Code Not Available
UNII 7RN5DR86CK
Synonyms pazopanib | GW 786034B | GW786034B | GW-786034B | GW 780604 | GW780604 | GW-780604 | Votrient
Chemical Information
Molecular Formula C21H23N7O2S
CAS Registry Number 444731-52-6
SMILES CC1=C(C=C(C=C1)NC2=NC=CC(=N2)N(C)C3=CC4=NN(C(=C4C=C3)C)C)S(=O)(=O)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.0010.009794%Not Available
Abdominal distension07.01.04.0010.003425%
Abdominal pain07.01.05.0020.011920%
Abdominal pain lower07.01.05.010--Not Available
Abdominal pain upper07.01.05.0030.012514%
Abdominal tenderness07.01.05.0040.000246%Not Available
Abnormal faeces07.01.03.0010.000492%Not Available
Accommodation disorder06.02.04.0010.000112%Not Available
Acute abdomen07.01.06.0150.000112%Not Available
Acute hepatic failure09.01.03.0010.000280%Not Available
Acute pulmonary oedema22.01.03.005; 02.05.02.0040.000224%Not Available
Acute respiratory distress syndrome22.01.03.001; 24.03.02.034; 10.02.01.0670.000280%
Ageusia17.02.07.001; 07.14.03.0030.006984%Not Available
Alanine aminotransferase increased13.03.04.005--
Albuminuria20.02.01.0010.000112%Not Available
Alopecia23.02.02.0010.009189%
Amnesia19.20.01.001; 17.03.02.0010.002082%
Amylase increased13.05.01.009--
Anaemia01.03.02.001--
Angina pectoris24.04.04.002; 02.02.02.0020.000336%
Angina unstable24.04.04.004; 02.02.02.0040.000112%Not Available
Anosmia17.04.04.001; 22.04.03.0060.000112%
Anuria20.01.03.0020.000224%Not Available
Aortic dissection24.02.03.0020.000224%Not Available
Aphasia19.21.01.001; 17.02.03.0010.000828%
Aphonia22.12.03.001; 19.19.01.002; 17.02.08.0090.000739%
Aphthous ulcer07.05.06.0020.000414%Not Available
Arterial thrombosis24.01.01.0020.000112%Not Available
Arteriovenous fistula24.03.03.0010.000112%Not Available
Arthralgia15.01.02.0010.009715%
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