Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Lifitegrast
Drug ID BADD_D01290
Description Lifitegrast is a FDA approved drug for the treatment of keratoconjunctivitis sicca (dry eye syndrome). It is a tetrahydroisoquinoline derivative and lymphocyte function-associated antigen-1 ( LFA-1) antagonist that was discovered through the rational design process. The ophthalmic solution was approved in July, 2016 under the trade name Xiidra. It has shown to protect the corneal surface and alleviate the symptoms of dry eye syndrome with fast onset of action and well tolerated profile in both local and systemic setting [A18805].
Indications and Usage For the treatment of signs and symptoms of keratoconjunctivitis sicca (dry eye syndrome).
Marketing Status Prescription
ATC Code S01XA25
DrugBank ID DB11611
KEGG ID D10374
MeSH ID C575157
PubChem ID 11965427
NDC Product Code 59116-5170; 66039-948; 71796-011; 0078-0911; 65392-2803; 65129-1428; 59651-445; 53296-0123; 58159-054; 17337-0431; 63592-3385; 66005-0049; 54092-606; 69766-074; 64552-4088; 16436-0123; 64552-4089
Synonyms lifitegrast | L-phenylalanine, n-((2-(6-benzofuranylcarbonyl)-5,7-dichloro-1,2,3,4-tetrahydro-6-isoquinolinyl)carbonyl)-3-(methylsulfonyl)- | (2S)-2-(((2-(benzofuran-6-ylcarbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinolin-6- yl)carbonyl)amino)-3-(3-(methylsulfonyl)phenyl)propanoic acid | Xiidra | SHP-606 | SHP606 | lifitegrast ophthalmic solution | SAR 1118 | SAR-1118
Chemical Information
Molecular Formula C29H24Cl2N2O7S
CAS Registry Number 1025967-78-5
SMILES CS(=O)(=O)C1=CC=CC(=C1)CC(C(=O)O)NC(=O)C2=C(C=C3CN(CCC3=C2Cl)C(=O)C4=CC5=C(C=C4) C=CO5)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.0010.008263%Not Available
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.003--
Abnormal sensation in eye06.01.01.0010.008263%Not Available
Ageusia17.02.07.001; Available
Asthenia08.01.01.001--Not Available
Asthenopia06.01.01.0020.007345%Not Available
Back pain15.03.04.005--
Blepharitis23.03.04.012; Available
Blindness17.17.01.003; Available
Blister23.03.01.001; Available
Blood pressure abnormal13.14.03.0010.001836%Not Available
Blood pressure increased13.14.03.005--Not Available
Burning sensation17.02.06.001; Available
Cellulitis11.02.01.001; Available
Chest discomfort22.02.08.001;; Available
Chest pain22.02.08.003;; Available
Conjunctival oedema06.04.01.0010.001836%Not Available
Conjunctivitis allergic10.01.04.002; Available
Corneal abrasion12.01.04.001; Available
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