Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Dimethyl fumarate
Drug ID BADD_D00680
Description Dimethyl fumarate is an anti-inflammatory. It is indicated for multiple sclerosis patients with relapsing forms and is also being investigated for the treatment of psoriasis. The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MMF up-regulates the Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway that is activated in response to oxidative stress. Dimethyl fumarate is marketed under the brand name Tecfidera.
Indications and Usage Used in multiple sclerosis patients with relapsing forms.
Marketing Status Prescription
ATC Code L04AX07
DrugBank ID DB08908
KEGG ID D03846
MeSH ID D000069462
PubChem ID 637568
TTD Drug ID D0A7MY
NDC Product Code 64406-007; 68180-776; 63759-0027; 68180-777; 69097-322; 59651-061; 70710-1205; 43598-429; 51407-441; 69238-1318; 82245-0105; 62207-003; 16729-416; 31722-657; 67877-555; 69238-1626; 43598-430; 58159-013; 69539-043; 16729-417; 31722-658; 54864-663; 64406-006; 55111-975; 70710-1416; 69238-1319; 71348-100; 10920-598; 65015-844; 0093-9218; 59285-003; 62512-0074; 62579-301; 50379-0013; 24979-127; 24979-129; 76055-0026; 70771-1532; 71348-101; 69037-0012; 55111-997; 24979-128; 64406-005; 69097-323; 69667-1229; 69539-240; 70710-1204; 0093-9219; 31722-680; 69539-042; 49812-0255; 0378-0396; 66577-043; 69097-552; 68180-778; 70771-1531; 70771-1530; 0378-0399; 51407-442; 50090-5288; 62675-0393; 67877-556; 66039-901; 67877-557; 62756-178; 71348-102
Synonyms Dimethyl Fumarate | Fumarate, Dimethyl | 2-butenedioic acid, (2E)-, dimethyl ester | Dimethylfumarate | BG 00012 | 00012, BG | BG00012 | BG-00012 | Tecfidera | FAG 201 | 201, FAG | FAG201 | FAG-201 | Fumaderm | BG 12 compound | 12 compound, BG | compound, BG 12 | BG12 compound | compound, BG12 | BG-12 compound
Chemical Information
Molecular Formula C6H8O4
CAS Registry Number 624-49-7
SMILES COC(=O)C=CC(=O)OC
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.0010.253046%Not Available
Abdominal distension07.01.04.0010.107270%
Abdominal pain07.01.05.0020.265882%
Abdominal pain lower07.01.05.010--Not Available
Abdominal pain upper07.01.05.0030.423578%
Abdominal rigidity07.01.05.0110.002751%Not Available
Abdominal tenderness07.01.05.0040.004584%Not Available
Abnormal faeces07.01.03.0010.004584%Not Available
Abortion18.01.01.0010.005501%Not Available
Abortion missed18.01.01.0020.006418%Not Available
Abortion spontaneous18.01.04.0010.128357%Not Available
Abscess11.01.08.001--Not Available
Acidosis14.01.03.002--
Acne23.02.01.0010.017420%Not Available
Actinic keratosis23.01.06.001--Not Available
Acute febrile neutrophilic dermatosis23.03.03.033; 01.02.01.0060.001834%Not Available
Acute myeloid leukaemia16.01.05.001; 01.10.05.001--Not Available
Acute myocardial infarction24.04.04.001; 02.02.02.001--Not Available
Acute respiratory failure14.01.04.004; 22.02.06.001--Not Available
Adenocarcinoma16.16.01.0040.000478%Not Available
Adrenal insufficiency14.11.01.004; 05.01.02.001--
Affective disorder19.04.04.001--Not Available
Ageusia17.02.07.001; 07.14.03.003--Not Available
Aggression19.05.01.001--Not Available
Agitation19.06.02.001; 17.02.05.012--
Agranulocytosis01.02.03.001--Not Available
Alanine aminotransferase abnormal13.03.01.0010.003667%Not Available
Alanine aminotransferase increased13.03.01.0030.043091%
Albumin urine present13.13.02.012--Not Available
Alcoholism19.07.02.0010.001834%Not Available
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