Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Chronic myeloid leukaemia
ADR ID BADD_A00933
ADR Hierarchy
01      Blood and lymphatic system disorders
01.10      Leukaemias
01.10.07      Leukaemias chronic myeloid
01.10.07.001      Chronic myeloid leukaemia
16      Neoplasms benign, malignant and unspecified (incl cysts and polyps)
16.01      Leukaemias
16.01.07      Leukaemias chronic myeloid
16.01.07.001      Chronic myeloid leukaemia
Description Clonal hematopoetic disorder caused by an acquired genetic defect in PLURIPOTENT STEM CELLS. It starts in MYELOID CELLS of the bone marrow, invades the blood and then other organs. The condition progresses from a stable, more indolent, chronic phase (LEUKEMIA, MYELOID, CHRONIC PHASE) lasting up to 7 years, to an advanced phase composed of an accelerated phase (LEUKEMIA, MYELOID, ACCELERATED PHASE) and BLAST CRISIS. [MeSH]
MedDRA Code 10009013
MeSH ID D015464
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Chronic granulocytic leukaemia | Chronic granulocytic leukemia | Chronic myelocytic leukemia | Chronic myelogenous leukemia | Chronic myeloid leukaemia | Chronic myeloid leukemia | Chronic myeloid leukemia without mention of remission | CML | Leukemia myelocytic chronic | Myeloid leukaemia, chronic | Myeloid leukemia, chronic | Non-lymphocytic leukaemia chronic | Non-lymphocytic leukemia chronic | Accelerated phase chronic myologenic leukaemia | Chronic phase chronic myeloid leukaemia | Accelerated phase chronic myologenic leukemia | Chronic phase chronic myeloid leukemia | Chronic myelocytic leukaemia | Chronic myelogenous leukaemia | Leukaemia myelocytic chronic | Chronic myeloid leukaemia without mention of remission | CML progression | Leukemia, Myelogenous, Chronic, BCR-ABL Positive | Leukemia, Chronic Myelogenous | Leukemia, Chronic Myeloid | Leukemia, Granulocytic, Chronic | Leukemia, Myelocytic, Chronic | Leukemia, Myelogenous, Chronic | Leukemia, Myelogenous, Ph1 Positive | Leukemia, Myelogenous, Ph1-Positive | Leukemia, Myeloid, Chronic | Leukemia, Myeloid, Ph1 Positive | Leukemia, Myeloid, Ph1-Positive | Leukemia, Myeloid, Philadelphia Positive | Leukemia, Myeloid, Philadelphia-Positive | Myelocytic Leukemia, Chronic | Chronic Myelocytic Leukemia | Chronic Myelocytic Leukemias | Leukemia, Chronic Myelocytic | Leukemias, Chronic Myelocytic | Myelocytic Leukemias, Chronic | Myelogenous Leukemia, Chronic | Chronic Myelogenous Leukemia | Chronic Myelogenous Leukemias | Leukemias, Chronic Myelogenous | Myelogenous Leukemias, Chronic | Myelogenous Leukemia, Ph1-Positive | Leukemia, Ph1-Positive Myelogenous | Leukemias, Ph1-Positive Myelogenous | Myelogenous Leukemia, Ph1 Positive | Myelogenous Leukemias, Ph1-Positive | Ph1-Positive Myelogenous Leukemia | Ph1-Positive Myelogenous Leukemias | Myeloid Leukemia, Chronic | Chronic Myeloid Leukemia | Chronic Myeloid Leukemias | Leukemias, Chronic Myeloid | Myeloid Leukemias, Chronic | Myeloid Leukemia, Ph1-Positive | Leukemia, Ph1-Positive Myeloid | Leukemias, Ph1-Positive Myeloid | Myeloid Leukemia, Ph1 Positive | Myeloid Leukemias, Ph1-Positive | Ph1-Positive Myeloid Leukemia | Ph1-Positive Myeloid Leukemias | Myeloid Leukemia, Philadelphia-Positive | Leukemia, Philadelphia-Positive Myeloid | Leukemias, Philadelphia-Positive Myeloid | Myeloid Leukemia, Philadelphia Positive | Myeloid Leukemias, Philadelphia-Positive | Philadelphia-Positive Myeloid Leukemia | Philadelphia-Positive Myeloid Leukemias | Granulocytic Leukemia, Chronic | Chronic Granulocytic Leukemia | Chronic Granulocytic Leukemias | Granulocytic Leukemias, Chronic | Leukemia, Chronic Granulocytic | Leukemias, Chronic Granulocytic
ADR Related Proteins
Protein Name UniProt AC TTD Target ID
LeptinP41159T79485
Tyrosine-protein kinase ABL1P00519T63505
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00139Anagrelide--
BADD_D00151Apixaban--
BADD_D00194Azacitidine--
BADD_D00195Azathioprine--
BADD_D00280Bleomycin--
BADD_D00286Bosutinib--
BADD_D00318Busulfan--
BADD_D00364Carboplatin--
BADD_D00474Cisplatin--
BADD_D00511Clozapine--
BADD_D00589Dasatinib--
BADD_D00680Dimethyl fumarate--
BADD_D00858Everolimus--
BADD_D01110Hydroxyurea--
BADD_D01136Imatinib--
BADD_D01220Ivacaftor--
BADD_D01253Lenalidomide--
BADD_D01567Nilotinib--
BADD_D01609Omacetaxine mepesuccinate--
BADD_D01633Oxaliplatin--
BADD_D01687Pazopanib--
BADD_D01728Pentosan polysulfate--
BADD_D01799Ponatinib--
BADD_D02100Sunitinib--
BADD_D02105Tacrolimus--
BADD_D02153Teniposide--
BADD_D02192Thalidomide--
BADD_D02236Tofacitinib--
BADD_D02329Valproic acid--
BADD_D02331Valsartan--
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