Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cladribine
Drug ID BADD_D00479
Description An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia.
Indications and Usage For the treatment of active hairy cell leukemia (leukemic reticuloendotheliosis) as defined by clinically significant anemia, neutropenia, thrombocytopenia, or disease-related symptoms. Also used as an alternative agent for the treatment of chronic lymphocytic leukemia (CLL), low-grade non-Hodgkin's lymphoma, and cutaneous T-cell lymphoma.
Marketing Status Prescription; Discontinued
ATC Code L01BB04; L04AA40
DrugBank ID DB00242
KEGG ID D01370
MeSH ID D017338
PubChem ID 20279
TTD Drug ID D05GJW
NDC Product Code 65129-1260; 67457-450; 63323-140; 42658-010; 54893-0115; 59605-3006; 58623-0037; 12502-4912; 0143-9871; 12502-5406; 44087-4000
Synonyms Cladribine | 2-Chlorodeoxyadenosine | 2-Chloro-2'-deoxyadenosine | 2'-Deoxy-2-chloroadenosine | Leustatin
Chemical Information
Molecular Formula C10H12ClN5O3
CAS Registry Number 4291-63-8
SMILES C1C(C(OC1N2C=NC3=C(N=C(N=C32)Cl)N)CO)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.0030.001095%
Abscess11.01.08.0010.000730%Not Available
Abscess bacterial11.02.01.027--Not Available
Administration site reaction12.07.04.011; 08.02.04.011--Not Available
Alanine aminotransferase increased13.03.01.0030.002189%
Alopecia23.02.02.0010.001825%
Altered state of consciousness17.02.04.001; 19.07.01.003--Not Available
Amyloidosis10.02.05.001--Not Available
Anaemia01.03.02.001--
Anxiety19.06.02.002--
Aplastic anaemia01.03.03.002--Not Available
Arrhythmia02.03.02.001--Not Available
Arthralgia15.01.02.0010.001095%
Arthritis15.01.01.001--
Aspartate aminotransferase increased13.03.01.0060.001460%
Asthenia08.01.01.001--Not Available
Ataxia17.02.02.001; 08.01.02.004--
Atrial fibrillation02.03.03.002--
B-cell lymphoma16.28.01.001; 01.15.01.0010.000190%Not Available
Back pain15.03.04.0050.001095%
Bacteraemia11.01.11.001--
Basal cell carcinoma23.08.02.001; 16.03.02.0010.001460%Not Available
Bladder cancer16.08.01.001; 20.03.04.0010.000190%Not Available
Blepharitis23.03.04.012; 06.04.04.001--Not Available
Blood bilirubin increased13.03.01.0080.000730%
Blood uric acid increased13.02.04.001--Not Available
Body temperature increased13.15.01.001--Not Available
Bone disorder15.02.04.004--Not Available
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