Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Aortic valve incompetence
ADR ID BADD_A00287
ADR Hierarchy
02      Cardiac disorders
02.07      Cardiac valve disorders
02.07.03      Aortic valvular disorders
02.07.03.001      Aortic valve incompetence
Description Pathological condition characterized by the backflow of blood from the ASCENDING AORTA back into the LEFT VENTRICLE, leading to regurgitation. It is caused by diseases of the AORTIC VALVE or its surrounding tissue (aortic root). [MeSH]
MedDRA Code 10002915
MeSH ID D001022; D001022; D001022
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Aortic incompetence | Aortic regurgitation | Aortic valve incompetence | Rheumatic aortic incompetence | Rheumatic aortic insufficiency | Aortic valve insufficiency | Aortic Valve Insufficiency | Insufficiency, Aortic Valve | Aortic Regurgitation | Regurgitation, Aortic | Regurgitation, Aortic Valve | Aortic Incompetence | Incompetence, Aortic | Aortic Valve Incompetence | Incompetence, Aortic Valve
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00066Alendronic acid0.000330%
BADD_D00085Alprazolam0.000019%
BADD_D00100Ambrisentan0.000120%
BADD_D00151Apixaban0.000108%
BADD_D00230Bendamustine0.000168%
BADD_D00259Betaine0.004312%
BADD_D00277Bisoprolol0.000471%
BADD_D00304Bromocriptine0.001319%
BADD_D00312Bupropion0.000028%
BADD_D00329Cabergoline0.004804%
BADD_D00367Carfilzomib0.000112%
BADD_D00405Ceftriaxone0.004457%
BADD_D00410Celecoxib--
BADD_D00504Clopidogrel0.000021%
BADD_D00511Clozapine0.003669%
BADD_D00563Dabigatran0.000489%
BADD_D00581Daptomycin0.000049%
BADD_D00589Dasatinib0.000112%
BADD_D00593Decitabine0.000112%
BADD_D00668Digoxin0.000211%
BADD_D00809Escitalopram0.000019%
BADD_D00858Everolimus0.000229%
BADD_D00932Fluoxetine0.000059%
BADD_D01244Lanreotide acetate--
BADD_D01285Levothyroxine0.000005%
BADD_D01319Lorcaserin hydrochloride--
BADD_D01378Memantine--
BADD_D01470Minocycline0.000295%
BADD_D01567Nilotinib0.000392%
BADD_D01599Olanzapine0.000631%
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