Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Lorcaserin hydrochloride
Drug ID BADD_D01319
Description Lorcaserin (previously APD-356), a highly selective 5HT2C receptor agonist, is used for the treatment of obesity. It has been shown to reduce body weight and food intake in animal models of obesity, and it is thought that targeting the 5HT2C receptor may alter body weight by regulating satiety. Lorcaserin is marketed as a salt form called Belviq, which is lorcaserin hydrochloride.
Indications and Usage For the treatment of obesity, as an adjunct to a reduced-calorie diet and increased physical activity.
Marketing Status Prescription
ATC Code A08AA11
DrugBank ID DB04871
KEGG ID D06613
MeSH ID C506658
PubChem ID 11673085
TTD Drug ID D01JMC
NDC Product Code 53296-0112; 16436-0112; 14501-0023
Synonyms lorcaserin | (1R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine | Belviq | AR-10A | 8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine | APD 356 | APD356 | APD-356
Chemical Information
Molecular Formula C11H15Cl2N
CAS Registry Number 846589-98-8
SMILES CC1CNCCC2=C1C=C(C=C2)Cl.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abnormal sensation in eye06.01.01.001--Not Available
Anxiety19.06.02.002--
Aortic valve incompetence02.07.03.001--Not Available
Asthenia08.01.01.001--Not Available
Back pain15.03.04.005--
Blood prolactin increased13.10.03.002--Not Available
Cardiac failure congestive02.05.01.002--Not Available
Cataract06.06.01.001--
Chills15.05.03.016; 08.01.09.001--
Confusional state17.02.03.005; 19.13.01.001--
Conjunctivitis11.01.06.012; 06.04.01.002--
Constipation07.02.02.001--
Cough22.02.03.001--
Depression19.15.01.001--
Dermatitis23.03.04.002--Not Available
Diabetes mellitus05.06.01.001; 14.06.01.001--Not Available
Diarrhoea07.02.01.001--
Disorientation19.13.01.002; 17.02.05.015--Not Available
Disturbance in attention19.21.02.002; 17.03.03.001--
Dizziness17.02.05.003; 02.01.02.004; 24.06.02.007--
Drug abuse19.07.02.010--Not Available
Drug hypersensitivity10.01.01.001--Not Available
Dry eye06.08.02.001--
Dry mouth07.06.01.002--
Euphoric mood19.04.02.006--
Eye disorder06.08.03.001--Not Available
Eye irritation06.04.05.003--Not Available
Fatigue08.01.01.002--
Feeling abnormal08.01.09.014--Not Available
Gastroenteritis11.01.07.004; 07.19.03.001--Not Available
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