Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Peripheral arterial occlusive disease
ADR ID BADD_A06121
ADR Hierarchy
24      Vascular disorders
24.04      Arteriosclerosis, stenosis, vascular insufficiency and necrosis
24.04.03      Peripheral vasoconstriction, necrosis and vascular insufficiency
24.04.03.010      Peripheral arterial occlusive disease
Description Common occlusive arterial disease which is caused by ATHEROSCLEROSIS. It is characterized by lesions in the innermost layer (ARTERIAL INTIMA) of arteries including the AORTA and its branches to the extremities. Risk factors include smoking, HYPERLIPIDEMIA, and HYPERTENSION. [MeSH]
MedDRA Code 10062585
MeSH ID D001162; D058729
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Arterial insufficiency peripheral | Atherosclerosis obliterans | Atherosclerosis of arteries of the extremities | Atherosclerosis of arteries of the extremities with gangrene | Atherosclerosis of arteries of the extremities with intermittent claudication | Atherosclerosis of arteries of the extremities with rest pain | Atherosclerosis of arteries of the extremities with ulceration | Atherosclerosis of arteries of the extremities, unspecified | Atherosclerosis of autologous vein bypass graft of the extremities | Atherosclerosis of bypass graft of the extremities | Atherosclerosis of nonautologous vein bypass graft of the extremities | Atherosclerosis of unspecified graft of the extremities | Obstructive arteriosclerosis of lower extremities | Other atherosclerosis of arteries of the extremities | Atherosclerosis of non-autologous vein bypass graft of the extremities | Peripheral occlusive disease | Peripheral arterial occlusive disease | Arteriosclerosis obliterans | Atherosclerosis obliterans aggravated | Peripheral arterial occlusive disease aggravated | Peripheral arterial disease | Peripheral obliterative arteriopathy | Peripheral arteriosclerosis | Peripheral arterial occlusive disease Fontaine stage I | Peripheral arterial occlusive disease Fontaine stage IIa | Peripheral arterial occlusive disease Fontaine stage IIb | Peripheral arterial occlusive disease Fontaine stage III | Peripheral arterial occlusive disease Fontaine stage IV | Arteriosclerosis Obliterans | Obliterans, Arteriosclerosis
ADR Related Proteins
Protein Name UniProt AC TTD Target ID
Not AvailableNot AvailableNot Available
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00066Alendronic acid0.001111%
BADD_D00076Allopurinol0.000132%
BADD_D00151Apixaban0.001192%
BADD_D00165Aripiprazole0.000149%
BADD_D00285Bosentan0.000671%
BADD_D00286Bosutinib0.000533%
BADD_D00344Canagliflozin0.001149%
BADD_D00347Candesartan cilexetil0.003855%
BADD_D00474Cisplatin0.000533%
BADD_D00504Clopidogrel0.000442%
BADD_D00551Cyclosporine0.000519%
BADD_D00564Dabigatran etexilate0.003165%
BADD_D00589Dasatinib0.001598%
BADD_D00623Dexamethasone0.001030%
BADD_D00732Droxidopa0.000097%
BADD_D00765Empagliflozin0.000749%
BADD_D00864Ezetimibe0.000314%
BADD_D00899Fingolimod hydrochloride--
BADD_D01136Imatinib0.003463%
BADD_D01253Lenalidomide--
BADD_D01401Metformin0.000078%
BADD_D01429Methylergonovine maleate--
BADD_D01445Metoprolol0.000031%
BADD_D01507Mycophenolate mofetil0.001308%
BADD_D01567Nilotinib0.034900%
BADD_D01668Pantoprazole0.000161%
BADD_D01799Ponatinib0.000764%
BADD_D01835Pregabalin--
BADD_D01867Propranolol--
BADD_D01954Rivaroxaban0.002677%
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