Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Dapagliflozin
Drug ID BADD_D00578
Description Dapagliflozin is a sodium-glucose cotransporter 2 inhibitor indicated for managing diabetes mellitus type 2.[A6757] When combined with diet and exercise in adults, dapagliflozin helps to improve glycemic control by inhibiting glucose resorption in the proximal tubule of the nephron and causing glycosuria.[A6757] Dapagliflozin was approved by the FDA on Jan 08, 2014.[L6034]
Indications and Usage Dapagliflozin is indicated for adjunct management of glycemic control in patients with type 2 diabetes mellitus, in combination with diet and exercise.
Marketing Status Prescription
ATC Code A10BK01
DrugBank ID DB06292
KEGG ID D08897
MeSH ID C529054
PubChem ID 9887712
NDC Product Code 17228-6205; 50090-3482; 14501-0028; 55154-6932; 59285-012; 66529-0003; 54921-621; 55111-987; 69037-0027; 65727-073; 12783-1428; 50090-3481; 0310-6205; 17228-6210; 12783-1427; 54921-620; 55154-6933; 46708-897; 66064-1029; 50193-1427; 59651-135; 0310-6210; 66039-933
Synonyms dapagliflozin | (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6- (hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol | Farxiga | Forxiga | 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol | BMS 512148 | BMS512148 | BMS-512148
Chemical Information
Molecular Formula C21H25ClO6
CAS Registry Number 461432-26-8
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal pain07.01.05.0020.010250%
Abdominal pain upper07.01.05.003--
Anaphylactic reaction10.01.07.001;
Anaphylactic shock24.06.02.004; Available
Angina pectoris02.02.02.002;
Angina unstable24.04.04.004; Available
Angioedema23.04.01.001; Available
Asthenia08.01.01.001--Not Available
Autoimmune hepatitis10.04.09.001; Available
Back pain15.03.04.0050.007235%
Balanitis candida21.09.03.005; Available
Balanoposthitis21.09.03.0010.001809%Not Available
Bladder cancer20.03.04.001; Available
Bladder neoplasm20.03.04.002; Available
Bladder pain20.02.02.0010.001809%Not Available
Blister23.03.01.001; Available
Blood creatine increased13.13.01.0010.001809%Not Available
Blood creatinine increased13.13.01.0040.004823%
Blood glucose abnormal13.02.02.0080.001809%Not Available
Blood glucose increased13.02.02.0020.018690%Not Available
Blood potassium decreased13.11.01.0100.001206%Not Available
Blood pressure decreased13.14.03.002--Not Available
Blood pressure fluctuation24.06.01.002--Not Available
Blood pressure increased13.14.03.005--Not Available
Blood triglycerides increased13.12.03.0010.007235%Not Available
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