Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Gaze palsy
ADR ID BADD_A05431
ADR Hierarchy
06      Eye disorders
06.05      Ocular neuromuscular disorders
06.05.02      Ocular nerve and muscle disorders
06.05.02.014      Gaze palsy
17      Nervous system disorders
17.02      Neurological disorders NEC
17.02.05      Neurological signs and symptoms NEC
17.02.05.044      Gaze palsy
Description Disorders that feature impairment of eye movements as a primary manifestation of disease. These conditions may be divided into infranuclear, nuclear, and supranuclear disorders. Diseases of the eye muscles or oculomotor cranial nerves (III, IV, and VI) are considered infranuclear. Nuclear disorders are caused by disease of the oculomotor, trochlear, or abducens nuclei in the BRAIN STEM. Supranuclear disorders are produced by dysfunction of higher order sensory and motor systems that control eye movements, including neural networks in the CEREBRAL CORTEX; BASAL GANGLIA; CEREBELLUM; and BRAIN STEM. Ocular torticollis refers to a head tilt that is caused by an ocular misalignment. Opsoclonus refers to rapid, conjugate oscillations of the eyes in multiple directions, which may occur as a parainfectious or paraneoplastic condition (e.g., OPSOCLONUS-MYOCLONUS SYNDROME). (Adams et al., Principles of Neurology, 6th ed, p240) [MeSH]
MedDRA Code 10056696
MeSH ID D015835
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Eyeballs raise upward | Eyes gaze upward | Feeling of eyeball pulled upward | Palsy of conjugate gaze | Spasm of conjugate gaze | Upward deviation of eyes | Gaze palsy | Downward deviation of eyes | Prevost sign | Head and eye gaze deviation | Ocular Motility Disorders | Ocular Motility Disorder | Eye Movement Disorders | Eye Movement Disorder | Eye Motility Disorders | Eye Motility Disorder | Convergence Excess | Convergence Excesses | Excess, Convergence | Convergence Insufficiency | Convergence Insufficiencies | Insufficiencies, Convergence | Insufficiency, Convergence | Cyclophoria | Cyclophorias | Internuclear Ophthalmoplegia | Internuclear Ophthalmoplegias | Ophthalmoplegia, Internuclear | Ophthalmoplegias, Internuclear | Spasm of Conjugate Gaze | Conjugate Gaze Spasm | Conjugate Gaze Spasms | Gaze Spasms, Conjugate | Opsoclonus | Parinaud Syndrome | Syndrome, Parinaud | Parinaud's Syndrome | Parinauds Syndrome | Syndrome, Parinaud's | Paroxysmal Ocular Dyskinesia | Dyskinesia, Paroxysmal Ocular | Dyskinesias, Paroxysmal Ocular | Ocular Dyskinesia, Paroxysmal | Ocular Dyskinesias, Paroxysmal | Paroxysmal Ocular Dyskinesias | Pseudoophthalmoplegia | Pseudoophthalmoplegias | Skew Deviation | Deviation, Skew | Deviations, Skew | Skew Deviations | Smooth Pursuit Deficiency | Deficiencies, Smooth Pursuit | Pursuit Deficiencies, Smooth | Pursuit Deficiency, Smooth | Smooth Pursuit Deficiencies | Deficiency, Smooth Pursuit | Brown Tendon Sheath Syndrome | Syndrome, Brown's Tendon Sheath | Tendon Sheath Syndrome of Brown | Brown's Tendon Sheath Syndrome | Ocular Torticollis
ADR Related Proteins
Protein Name UniProt AC TTD Target ID
Not AvailableNot AvailableNot Available
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00165Aripiprazole0.000954%
BADD_D00167Armodafinil0.002281%
BADD_D00312Bupropion0.000176%
BADD_D00356Carbamazepine0.001684%
BADD_D00475Citalopram0.000167%
BADD_D00504Clopidogrel0.000343%
BADD_D00564Dabigatran etexilate0.002110%
BADD_D00623Dexamethasone0.000687%
BADD_D00686Diphenhydramine0.000198%
BADD_D00931Fluorouracil0.001411%
BADD_D01238Lacosamide0.010056%
BADD_D01243Lamotrigine0.000387%
BADD_D01265Levetiracetam0.000381%
BADD_D01378Memantine0.000576%
BADD_D01442Metoclopramide0.001087%
BADD_D01449Metronidazole0.000208%
BADD_D01465Miglustat0.011145%
BADD_D01496Montelukast0.000069%
BADD_D01498Morphine0.000469%
BADD_D01637Oxcarbazepine0.000831%
BADD_D01656Paliperidone0.009391%
BADD_D01835Pregabalin0.000236%
BADD_D01913Ranitidine0.000105%
BADD_D01951Risperidone0.001073%
BADD_D01954Rivaroxaban--
BADD_D02105Tacrolimus0.000555%
BADD_D02329Valproic acid0.001772%
BADD_D02394Zolpidem0.000109%
BADD_D02464Fingolimod0.001737%
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