Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Oxcarbazepine
Drug ID BADD_D01637
Description Oxcarbazepine is an anti-epileptic medication used in the treatment of partial onset seizures that was first approved for use in the United States in 2000.[L8627,L8630,L863] It is a structural derivative of [carbamazepine][A186101] and exerts a majority of its activity via a pharmacologically active metabolite, MHD, which exists as a racemate in the blood - a pro-drug of the more active (S)-enantiomer is also marketed as a separate anti-epileptic under the name [eslicarbazepine].[A186011] Compared to other anti-epileptic drugs, which are generally metabolized via the cytochrome P450 system, oxcarbazepine has a reduced propensity for involvement in drug-drug interactions owing to its primarily reductive metabolism.[A186032]
Indications and Usage For use as monotherapy or adjunctive therapy in the treatment of partial seizures in adults with epilepsy and as adjunctive therapy in the treatment of partial seizures in children ages 4-16 with epilepsy.
Marketing Status Prescription; Discontinued
ATC Code N03AF02
DrugBank ID DB00776
KEGG ID D00533
MeSH ID D000078330
PubChem ID 34312
TTD Drug ID D0QL3P
NDC Product Code 55289-007; 76047-001; 48087-0115; 71335-0144; 31722-023; 82334-001; 48087-0046; 68084-867; 48087-0158; 55512-0018; 50268-649; 55154-8198; 66406-0246; 63629-3816; 68462-137; 70518-1842; 50090-5003; 66406-0245; 65372-1104; 51991-293; 51508-008; 51991-292; 51672-4105; 68084-845; 70518-2253; 71428-007; 55512-0017; 70518-2377; 70518-2276; 51672-4106; 71335-0505; 55154-8187; 17772-122; 50383-312; 68084-853; 58159-088; 60429-061; 70518-3237; 72189-339; 55512-0006; 0615-8292; 66406-0244; 70518-3127; 68788-7866; 68462-138; 17772-123; 51672-4107; 63629-2075; 0615-8153; 48087-0118; 68462-139; 31722-025; 48087-0157; 66039-905; 0078-0456; 69766-055; 55512-0008; 70518-1027; 70518-0894; 0781-6270; 71205-411; 70518-1055; 42419-006; 0078-0457; 48087-0114; 71335-0090; 62756-183; 0078-0337; 70518-2254; 60429-062; 62512-0058; 31722-024; 55512-0023; 55512-0016; 68094-123; 55700-868; 60429-063; 51991-294; 72761-033; 0054-0199; 55512-0007; 63629-4987; 63629-6834; 42419-029; 70518-2370; 17772-121; 62756-185; 0078-0357; 70966-0004; 62756-184; 70518-1980; 70518-3197; 12658-0588; 65162-649
Synonyms Oxcarbazepine | 10,11-Dihydro-10-oxo-5H-dibenz(b,f)azepine-5-carboxamide | Trileptal | Timox | GP 47680
Chemical Information
Molecular Formula C15H12N2O2
CAS Registry Number 28721-07-5
SMILES C1C2=CC=CC=C2N(C3=CC=CC=C3C1=O)C(=O)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.003--
Abortion spontaneous18.01.04.0010.013298%Not Available
Accommodation disorder06.02.04.001--Not Available
Acne23.02.01.001--Not Available
Aggression19.05.01.0010.004571%Not Available
Agitation19.06.02.001; 17.02.05.0120.003325%
Agranulocytosis01.02.03.0010.001247%Not Available
Alanine aminotransferase increased13.03.01.0030.002078%
Alopecia23.02.02.001--
Altered state of consciousness19.07.01.003; 17.02.04.0010.001247%Not Available
Amnesia19.20.01.001; 17.03.02.0010.002493%
Anaemia01.03.02.001--
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Anger19.04.02.0010.001662%Not Available
Angina pectoris24.04.04.002; 02.02.02.0020.000831%
Angioedema23.04.01.001; 10.01.05.009--Not Available
Anxiety19.06.02.0020.007480%
Apathy19.04.04.002--Not Available
Apgar score low13.15.01.0120.000831%Not Available
Aphasia19.21.01.001; 17.02.03.001--
Aplastic anaemia01.03.03.002--Not Available
Arrhythmia02.03.02.0010.001247%Not Available
Arthralgia15.01.02.001--
Aspartate aminotransferase increased13.03.01.0060.001662%
Asthenia08.01.01.001--Not Available
Asthma22.03.01.002; 10.01.03.010--Not Available
Ataxia08.01.02.004; 17.02.02.0010.002909%
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