Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Metoclopramide
Drug ID BADD_D01442
Description Diabetic gastroparesis is a condition that causes frequent nausea and vomiting, which has a negative impact on quality of life and poses a significant burden on the healthcare system.[A184934] Metoclopramide is a dopamine antagonist used to treat nausea and vomiting that may be associated with diabetic gastroparesis in addition to gastroesophageal reflux disease (GERD). It can also be used to prevent nausea or vomiting associated with chemotherapy or certain surgical or diagnostic procedures.[L8417] One unique property of this drug is that it does not increase gastric acid secretion. It is available in the oral tablet form or in solution, and can also be administered through the intravenous route.[T683] Metoclopramide was initially approved by the FDA in 1980.[A184922]
Indications and Usage For the treatment of gastroesophageal reflux disease (GERD). It is also used in treating nausea and vomiting, and to increase gastric emptying.
Marketing Status Prescription; Discontinued
ATC Code A03FA01
DrugBank ID DB01233
KEGG ID D00726
MeSH ID D008787
PubChem ID 4168
TTD Drug ID D08VYV
NDC Product Code 63187-404; 51079-888; 0093-2204; 51662-1367; 0615-8285; 63629-2144; 70518-0669; 42291-596; 60687-620; 55154-8196; 0409-3414; 43353-274; 51662-1288; 70518-1193; 66267-841; 71872-7075; 62559-190; 62559-295; 71872-7076; 68084-676; 60687-631; 71335-0362; 42291-595; 68788-7930; 50090-0132; 55154-4383; 66267-286; 49884-689; 68071-4569; 68788-7226; 0703-4502; 67296-0855; 62559-296; 63187-235; 0615-7698; 71335-0790; 0093-2203; 49999-057; 66267-827; 68071-4326; 51079-886; 50090-2221; 63629-7967; 63629-1961; 63629-8745
Synonyms Metoclopramide | 4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide | Metaclopramide | Maxolon | Rimetin | Metoclopramide Hydrochloride | Hydrochloride, Metoclopramide | Metoclopramide Monohydrochloride | Monohydrochloride, Metoclopramide | Metoclopramide Monohydrochloride, Monohydrate | Primperan | Reglan | Cerucal | Metoclopramide Dihydrochloride | Dihydrochloride, Metoclopramide
Chemical Information
Molecular Formula C14H22ClN3O2
CAS Registry Number 364-62-5
SMILES CCN(CC)CCNC(=O)C1=CC(=C(C=C1OC)N)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.003--
Acute hepatic failure09.01.03.0010.000473%Not Available
Acute pulmonary oedema22.01.03.005; 02.05.02.0040.000725%Not Available
Acute respiratory distress syndrome22.01.03.0010.002174%
Acute respiratory failure22.02.06.001; 14.01.04.0040.000662%Not Available
Agitation17.02.05.012; 19.06.02.001--
Agranulocytosis01.02.03.001--Not Available
Akathisia19.06.02.006; 17.01.02.0020.048564%
Akinesia17.01.02.003--Not Available
Altered state of consciousness19.07.01.003; 17.02.04.001--Not Available
Amenorrhoea05.05.01.002; 21.01.02.001--
Amnesia19.20.01.001; 17.03.02.001--
Anaphylactic reaction24.06.03.006; 10.01.07.0010.003987%
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Angioedema23.04.01.001; 10.01.05.009--Not Available
Anhedonia19.15.02.0070.033705%Not Available
Anxiety19.06.02.0020.050013%
Aortic stenosis24.04.01.0010.001450%Not Available
Arthralgia15.01.02.001--
Asthenia08.01.01.001--Not Available
Asthma22.03.01.002; 10.01.03.010--Not Available
Ataxia17.02.02.001; 08.01.02.004--
Atrial fibrillation02.03.03.002--
Atrial septal defect03.07.02.002; 02.04.02.0090.001087%Not Available
Atrioventricular block02.03.01.002--Not Available
Autonomic nervous system imbalance24.06.01.005; 17.05.01.011; 08.01.01.010--Not Available
Back pain15.03.04.005--
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