Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Gabapentin
Drug ID BADD_D00981
Description Gabapentin is a structural analogue of the inhibitory neurotransmitter gamma-aminobutyric acid ([GABA]) that was first approved for use in the United States in 1993.[L8717] It was originally developed as a novel anti-epileptic for the treatment of certain types of seizures[A186277,A186143] - today it is also widely used to treat neuropathic pain.[A14097,A186179] Gabapentin has some stark advantages as compared with other anti-epileptics, such as a relatively benign adverse effect profile, wide therapeutic index, and lack of appreciable metabolism making it unlikely to participate in pharmacokinetic drug interactions.[A186143,A185981,L8717]. It is structurally and functionally related to another GABA derivative, [pregabalin].
Indications and Usage For the management of postherpetic neuralgia in adults and as adjunctive therapy in the treatment of partial seizures with and without secondary generalization in patients over 12 years of age with epilepsy.
Marketing Status Prescription; Discontinued
ATC Code N03AX12
DrugBank ID DB00996
KEGG ID D00332
MeSH ID D000077206
PubChem ID 3446
TTD Drug ID D0J0ZS
NDC Product Code 60760-066; 70010-118; 42582-116; 71093-162; 60760-517; 70518-2912; 60760-741; 63187-909; 69434-043; 71335-1018; 80425-0128; 69097-812; 51224-119; 55154-6846; 80425-0097; 70166-751; 50436-0428; 50436-0383; 61919-417; 68071-4784; 71610-631; 69097-811; 17856-0600; 64380-868; 76282-706; 43602-470; 76420-014; 59762-4355; 80425-0079; 0228-2637; 71610-146; 69097-814; 67877-224; 53002-3423; 0904-6586; 68071-2458; 68071-3086; 42582-115; 55154-3363; 68788-9509; 60687-580; 61919-350; 63187-785; 17351-5010; 63275-9970; 31722-167; 68071-4978; 50090-5045; 80425-0150; 71205-619; 71093-122; 63629-8488; 0904-6823; 63629-3063; 68071-4113; 52427-803; 71610-421; 16714-662; 52427-806; 71205-931; 65162-102; 55700-780; 70518-1469; 68071-4049; 63187-148; 69097-813; 71335-1348; 68071-3230; 53002-4423; 45865-405; 71610-432; 69434-044; 68788-7839; 70934-123; 57884-2002; 65841-706; 71335-2005; 65015-740; 71093-161; 65862-198; 50436-4290; 55154-7992; 43602-471; 71093-163; 50090-3912; 68788-7941; 69097-943; 62207-924; 68788-7098; 58657-720; 0615-8340; 69844-056; 70010-927; 45963-556; 62207-926; 63739-236; 71335-2004; 71335-0073; 43547-384; 43353-081; 50090-0896; 68788-7135; 0071-0805; 55370-004; 67296-1709; 59088-725; 70010-109; 71335-1997; 0071-0803; 55154-8194; 71335-1200; 43063-664; 70934-339; 71335-1041; 57884-2001; 43063-673; 72189-113; 42582-114; 62756-138; 62207-928; 62756-137; 50090-5125; 50090-4445; 71335-1454; 63187-010; 71335-1198; 68001-412; 50228-177; 71335-1026; 70010-926; 60760-067; 62756-204; 68788-7757; 55700-950; 59762-5050; 0615-8342; 71335-1313; 50090-5322; 55154-7989; 50228-178; 71205-457; 51407-048; 68788-7848; 63739-591; 16714-663; 71335-1490; 50228-181; 67296-1710; 50090-4893; 69367-132; 0395-8055; 76282-627; 42765-018; 62207-923; 53002-6423; 71335-0254; 68788-7104; 57884-0010; 43547-389; 60687-507; 55700-584; 72189-178; 0228-2636; 58657-722; 62756-202; 71335-0351; 60687-591; 55700-544; 55154-3366; 65162-698; 63187-983; 80425-0034; 69367-344; 65862-199; 70120-123; 43353-075; 67877-223; 50268-352; 60760-605; 67877-429; 71335-1093; 71610-442; 71335-0820; 71335-1601; 71610-400; 80425-0149; 63187-988; 72189-109; 71610-125; 61919-660; 70518-0810; 76420-047; 46144-104; 31722-150; 72789-123; 71205-160; 63187-392; 68788-7444; 69844-055; 65862-385; 59762-5025; 80425-0163; 70518-1288; 10135-647; 71610-135; 55154-6845; 68788-7847; 71335-1496; 70518-2776; 67296-1721; 70518-2614; 65862-523; 53746-102; 43547-385; 80425-0036; 63187-149; 42806-511; 42192-608; 65862-524; 68788-7869; 71610-059; 71610-426; 62207-927; 71205-532; 60592-300; 80425-0031; 51224-219; 68071-1292; 55700-815; 71610-410; 68788-7614; 65977-0054; 71335-1287; 71205-317; 71610-090; 63629-8060; 71205-929; 65841-705; 70010-928; 71093-112; 60687-602; 59762-4135; 68554-0128; 59762-4460; 68071-2600; 45865-356; 71335-1497; 70518-3330; 70518-2098; 70934-933; 71335-0993; 70518-0483; 63739-903; 80425-0035; 68382-205; 61919-640; 64380-867; 63739-904; 50228-180; 72189-092; 69367-135; 69097-815; 69367-347; 71610-195; 70518-1160; 72789-055; 59762-4030; 76282-707; 70518-2493; 71610-185; 16714-503; 80425-0033; 63187-248; 16714-661; 72789-127; 71205-932; 63629-7309; 60760-088; 63629-8492; 62756-139; 63629-8489; 31722-149; 63187-031; 43602-469; 52048-1980; 0071-0513; 76282-323; 68788-7431; 45963-555; 49483-607; 70934-593; 25000-105; 68382-204; 35356-708; 55700-949; 70934-651; 53002-5472; 68071-2308; 59762-4240; 71335-1453
Synonyms Gabapentin | 1-(Aminomethyl)cyclohexaneacetic Acid | Neurontin | Gabapentin Hexal | Convalis | Gabapentin-Ratiopharm | Gabapentin Ratiopharm | Novo-Gabapentin | Novo Gabapentin | NovoGabapentin | PMS-Gabapentin | Apo-Gabapentin | Apo Gabapentin | ApoGabapentin | Gabapentin Stada
Chemical Information
Molecular Formula C9H17NO2
CAS Registry Number 60142-96-3
SMILES C1CCC(CC1)(CC(=O)O)CN
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
AkathisiaD(1A) dopamine receptorP21728T2211811715630; 15738862; 15959450; 15627046
AnxietyHistamine H1 receptorP35367T7791311715630; 15738862; 15959450; 15627046
AnxietyMuscarinic acetylcholine receptor M1P11229T2889311715630; 15738862; 15959450; 15627046
AnxietyAlpha-1A adrenergic receptorP35348T9260911715630; 15738862; 15959450; 15627046
Anxiety5-hydroxytryptamine receptor 3AP46098T6459111715630; 15738862; 15959450; 15627046
Anxiety5-hydroxytryptamine receptor 2BP41595T3120411715630; 15738862; 15959450; 15627046
Anxiety5-hydroxytryptamine receptor 2AP28223T3206011715630; 15738862; 15959450; 15627046
Diabetic complications NECGlutamine--fructose-6-phosphate aminotransferase [isomerizing] 1Q06210Not Available11163803; 12802498; 10997922
Diabetic complications NECTransforming growth factor beta-1 proproteinP01137T9725711163803; 12802498; 10997922
Diabetic complications renalGlutamine--fructose-6-phosphate aminotransferase [isomerizing] 1Q06210Not Available11163803; 12802498; 10997922
Diabetic complications renalTransforming growth factor beta-1 proproteinP01137T9725711163803; 12802498; 10997922
DystoniaD(1A) dopamine receptorP21728T2211811715630; 15738862; 15959450; 15627046
Nausea5-hydroxytryptamine receptor 2BP41595T3120411715630; 15738862; 15959450; 15627046
Nausea5-hydroxytryptamine receptor 2AP28223T3206011715630; 15738862; 15959450; 15627046
NauseaHistamine H1 receptorP35367T7791311715630; 15738862; 15959450; 15627046
Nausea5-hydroxytryptamine receptor 3AP46098T6459111715630; 15738862; 15959450; 15627046
NauseaMuscarinic acetylcholine receptor M1P11229T2889311715630; 15738862; 15959450; 15627046
NauseaAlpha-1A adrenergic receptorP35348T9260911715630; 15738862; 15959450; 15627046
PainNot AvailableQ5SUY9Not Available9168217; 9655623
ParkinsonismD(1A) dopamine receptorP21728T2211811715630; 15738862; 15959450; 15627046
Sleep disturbances (incl subtypes)Muscarinic acetylcholine receptor M1P11229T2889311715630; 15738862; 15959450; 15627046
Sleep disturbances (incl subtypes)Alpha-1A adrenergic receptorP35348T9260911715630; 15738862; 15959450; 15627046
Sleep disturbances (incl subtypes)5-hydroxytryptamine receptor 2BP41595T3120411715630; 15738862; 15959450; 15627046
Sleep disturbances (incl subtypes)5-hydroxytryptamine receptor 2AP28223T3206011715630; 15738862; 15959450; 15627046
Sleep disturbances (incl subtypes)Histamine H1 receptorP35367T7791311715630; 15738862; 15959450; 15627046
Sleep disturbances (incl subtypes)5-hydroxytryptamine receptor 3AP46098T6459111715630; 15738862; 15959450; 15627046
Tardive dyskinesiaD(1A) dopamine receptorP21728T2211811715630; 15738862; 15959450; 15627046
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.0010.002340%Not Available
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.003--
Abnormal dreams19.02.03.001; 17.15.02.0010.000280%Not Available
Abnormal faeces07.01.03.001--Not Available
Abnormal palmar/plantar creases23.07.04.016; 03.05.01.0100.000102%Not Available
Abnormal weight gain14.03.02.0100.000178%Not Available
Abortion spontaneous18.01.04.001--Not Available
Abscess11.01.08.001--Not Available
Accommodation disorder06.02.04.001--Not Available
Acne23.02.01.001--Not Available
Acute febrile neutrophilic dermatosis23.03.03.033; 01.02.01.0060.000305%Not Available
Acute hepatic failure09.01.03.001--Not Available
Acute respiratory failure22.02.06.001; 14.01.04.004--Not Available
Affective disorder19.04.04.0010.000280%Not Available
Ageusia17.02.07.001; 07.14.03.0030.000254%Not Available
Aggression19.05.01.0010.001297%Not Available
Agitation19.06.02.001; 17.02.05.0120.002009%
Akathisia19.06.02.006; 17.01.02.0020.000254%
Alanine aminotransferase increased13.03.01.003--
Alcohol intolerance14.02.01.001--
Alcoholism19.07.02.0010.000153%Not Available
Alopecia23.02.02.001--
Altered state of consciousness17.02.04.001; 19.07.01.0030.000509%Not Available
Amblyopia06.02.01.001--Not Available
Amenorrhoea21.01.02.001; 05.05.01.002--
Amnesia19.20.01.001; 17.03.02.0010.002034%
Anaemia01.03.02.001--
Anaesthetic complication pulmonary22.02.07.005; 12.02.12.0070.000229%Not Available
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