Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Metronidazole
Drug ID BADD_D01449
Description Metronidazole is a commonly used antibiotic, belonging to the nitroimidazole class of antibiotics.[L3754] It is frequently used to treat gastrointestinal infections as well as trichomoniasis and giardiasis, and amebiasis which are parasitic infections.[A181036,A18039] Metronidazole has been used as an antibiotic for several decades[L7429], with added antiparasitic properties that set it apart from many other antibacterial drugs, allowing it to treat a wide variety of infections. It is available in capsule form, tablet form, and topical form, and suppository preparations for the treatment of various infections.
Indications and Usage For the treatment of anaerobic infections and mixed infections, surgical prophylaxis requiring anaerobic coverage, Clostridium difficile-associated diarrhea and colitis, Helicobacter pylori infection and duodenal ulcer disease, bacterial vaginosis, Giardia lamblia gastro-enteritis, amebiasis caused by Entamoeba histolytica, acne rosacea (topical treatment), and Trichomonas infections.
Marketing Status Prescription; Discontinued
ATC Code A01AB17; D06BX01; G01AF01; J01XD01; P01AB01
DrugBank ID DB00916
KEGG ID D00409
MeSH ID D008795
PubChem ID 4173
TTD Drug ID D0A2ZX
NDC Product Code 63187-511; 62332-630; 68788-6930; 68682-455; 68071-5073; 50090-0214; 50090-0202; 0025-1942; 15955-389; 60760-664; 71335-0858; 63629-1386; 23155-652; 63629-8731; 0395-8115; 64380-780; 63187-827; 72578-007; 71335-0358; 68071-5042; 69043-004; 61919-363; 50090-5248; 50090-0213; 25021-131; 72578-008; 73473-303; 0409-7811; 0904-7126; 68071-1753; 51672-4164; 68788-7815; 0409-0152; 60687-550; 60592-427; 43538-180; 50090-5307; 70518-1536; 50090-0212; 61919-032; 68071-2549; 50090-5247; 23155-651; 0404-9911; 55289-521; 70518-0797; 68071-5283; 16571-665; 36000-001; 46708-021; 53747-007; 68071-2251; 68071-2288; 61919-499; 45802-139; 70518-3042; 43538-182; 50268-534; 51672-4215; 16571-664; 70518-3265; 72789-195; 60760-336; 51927-1449; 50090-5688; 70518-2814; 0299-3838; 70518-3073; 70518-1241; 70934-915; 70934-813; 58118-0527; 70518-2663; 53002-2478; 52584-811; 68071-2280; 0781-7080; 0264-5535; 0187-5202; 70934-104; 62332-016; 50090-4494; 68071-1876; 66993-962; 29300-226; 71335-1838; 43063-738; 68071-2409; 53002-2471; 70518-3110; 45865-717; 62332-018; 70518-0088; 67296-1747; 71335-1609; 68071-5009; 68083-373; 72789-011; 63629-7940; 55700-909; 0713-0637; 66993-961; 68788-7955; 50111-333; 66993-960; 67296-1418; 51407-372; 71589-014; 51552-0038; 71209-063; 29300-227; 54348-740; 50090-1012; 49964-0002; 50090-5691; 70518-0324; 70934-524; 61919-385; 69043-005; 50090-5768; 62332-017; 68788-6960; 0781-7077; 70518-2305; 68071-2343; 46708-435; 65862-695; 67296-1806; 53002-7341; 0115-1474; 0338-9541; 49452-4726; 50090-5787; 0245-0860; 69292-208; 63629-1388; 70518-0013; 0338-1055; 71335-1775; 68001-365; 72789-007; 55154-8182; 43063-021; 71335-1681; 50111-334; 68462-184; 0713-0633; 50090-5687; 68981-034; 66993-936; 0168-0275; 0904-7156; 50268-535; 50090-0211; 46708-429; 63629-8680; 64380-779; 0713-0757; 60687-526; 55154-8190; 63629-7916; 50090-2512; 68071-2551; 50090-4392; 71209-062; 38779-0146; 68071-2449; 51407-376; 55154-0663; 68071-2399; 69292-207; 68001-364; 0299-3836; 47335-993; 67296-1366; 70518-0058; 55700-298; 65862-694; 43538-181; 70882-130; 67296-1283; 50090-5250; 70882-131; 0591-2521; 50090-0201; 51672-4116; 0591-5215; 71335-1922; 53002-2470; 63187-035; 53002-7340; 54348-745; 46708-428; 0299-3820; 66267-804; 0904-1453; 72789-005; 0642-7466; 43538-183; 50090-5249; 64980-235; 71335-1703; 64980-236; 15955-388; 50090-4809; 43063-719; 61919-788; 62991-1685
Synonyms Metronidazole | 2-Methyl-5-nitroimidazole-1-ethanol | 2 Methyl 5 nitroimidazole 1 ethanol | Satric | Trichazol | Trichopol | Trivazol | Metronidazole Phosphoester | Vagilen | Bayer 5360 | Metronidazole Phosphate | Danizol | Flagyl | Gineflavir | Metric | Metrodzhil | MetroGel | Metrogyl | Metronidazole Hydrochloride | Metronidazole Monohydrochloride | Clont
Chemical Information
Molecular Formula C6H9N3O3
CAS Registry Number 443-48-1
SMILES CC1=NC=C(N1CCO)[N+](=O)[O-]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal distension07.01.04.0010.000677%
Abdominal pain07.01.05.0020.002762%
Abdominal pain lower07.01.05.010--Not Available
Abdominal pain upper07.01.05.0030.002032%
Abdominal tenderness07.01.05.0040.000208%Not Available
Abortion incomplete18.01.01.0030.004794%Not Available
Abortion spontaneous18.01.04.0010.013810%Not Available
Acne23.02.01.001--Not Available
Activated partial thromboplastin time prolonged13.01.02.0010.000208%
Acute disseminated encephalomyelitis17.16.02.003; 10.04.10.0100.000104%Not Available
Acute hepatic failure09.01.03.0010.000544%Not Available
Acute myocardial infarction24.04.04.001; 02.02.02.001--Not Available
Acute psychosis19.03.01.0010.000417%Not Available
Acute pulmonary oedema22.01.03.005; 02.05.02.0040.000156%Not Available
Acute respiratory distress syndrome22.01.03.001--
Affective disorder19.04.04.0010.000156%Not Available
Aggression19.05.01.001--Not Available
Agitation19.06.02.001; 17.02.05.012--
Agranulocytosis01.02.03.0010.000365%Not Available
Alanine aminotransferase increased13.03.01.003--
Alcohol intolerance14.02.01.0010.000313%
Alopecia23.02.02.001--
Altered state of consciousness19.07.01.003; 17.02.04.0010.000521%Not Available
Amnesia19.20.01.001; 17.03.02.001--
Anaemia01.03.02.0010.001980%
Anaphylactic reaction24.06.03.006; 10.01.07.0010.002970%
Anaphylactic shock10.01.07.002; 24.06.02.0040.000625%Not Available
Anaphylactoid reaction10.01.07.003; 24.06.03.0070.000104%Not Available
Angioedema23.04.01.001; 10.01.05.0090.001615%Not Available
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