| Drug Name |
Risperidone |
| Drug ID |
BADD_D01951 |
| Description |
Risperidone is a second-generation antipsychotic (SGA) medication used in the treatment of a number of mood and mental health conditions including schizophrenia and bipolar disorder.[L12885] It is one of the most widely used SGAs. [Paliperidone], another commonly used SGA, is the primary active metabolite of risperidone (i.e. 9-hydroxyrisperidone).[L12885]
Schizophrenia and various mood disorders are thought to be caused by an excess of dopaminergic D2 and serotonergic 5-HT2A activity, resulting in overactivity of central mesolimbic pathways and mesocortical pathways, respectively.[L1212,L1213] Risperidone is thought to reduce this overactivity through inhibition of dopaminergic D2 receptors and serotonergic 5-HT2A receptors in the brain.[L1213,A1115]
Risperidone binds with a very high affinity to 5-HT2A receptors, approximately 10-20 fold greater than the drug's binding affinity to D2 receptors,[L1212,L1213,A1115] and carries lesser activity at several off-targets which may responsible for some of its undesirable effects.[L12885] |
| Indications and Usage |
Risperidone belongs to the class of medications known as second generation atypical antipsychotics [A1114, A1115, L1213]. It is widely used in the treatment of schizophrenia and mood disorders, including bipolar disorder and depression with pyschosis [A1115, A1116, L1212, L1213]. |
| Marketing Status |
Prescription; Discontinued |
| ATC Code |
N05AX08 |
| DrugBank ID |
DB00734
|
| KEGG ID |
D00426
|
| MeSH ID |
D018967
|
| PubChem ID |
5073
|
| TTD Drug ID |
D01AZG
|
| NDC Product Code |
68382-115; 52038-007; 70518-1575; 12578-303; 55111-204; 43547-339; 71205-520; 43063-254; 50090-3344; 43547-340; 70518-2969; 65841-640; 55700-082; 42291-908; 55111-471; 50458-301; 63187-264; 70518-1502; 68071-4618; 59746-050; 49884-315; 71610-246; 65757-725; 0904-6362; 0615-8288; 55111-201; 0904-6357; 50268-699; 65267-303; 43547-342; 55289-491; 65162-673; 65757-728; 50458-302; 42291-913; 64552-4011; 63304-950; 50268-697; 50090-2672; 68382-155; 55111-207; 70518-1574; 50458-315; 71335-0379; 69238-2113; 42291-911; 27808-002; 13668-039; 63629-2284; 71161-131; 64220-119; 42291-912; 50458-350; 27241-002; 49884-402; 50268-698; 55111-202; 68382-156; 42291-910; 55111-209; 50458-320; 27241-006; 59746-010; 50090-3341; 0904-6359; 55289-463; 59746-020; 68382-117; 0904-6358; 63629-2283; 63187-439; 65841-666; 40700-0031; 42291-909; 43353-412; 50458-325; 68382-112; 55111-205; 58118-0077; 63304-949; 71335-0130; 55700-897; 49884-212; 59746-040; 17856-0063; 70518-1763; 69238-2109; 50458-306; 50458-305; 63552-179; 50458-330; 49884-311; 63304-644; 0904-6360; 43353-720; 43063-908; 46602-0050; 43353-432; 65841-668; 71335-0740; 27241-004; 65372-1105; 12496-0090; 50458-309; 55111-208; 64567-0003; 68382-116; 69238-2111; 49884-403; 70518-0978; 63187-418; 65015-619; 71610-226; 0615-8198; 65841-641; 0054-0063; 63187-642; 70518-2130; 43547-343; 50458-335; 55111-203; 55111-869; 68084-271; 65841-665; 68071-2524; 70518-1568; 65267-895; 0904-6361; 13668-040; 53002-1596; 71610-264; 43547-344; 69238-2110; 63304-643; 50458-307; 27241-001; 53104-7555; 68084-270; 68382-113; 68382-154; 0615-8197; 13668-035; 49884-401; 68382-114; 68084-272; 0615-8265; 71610-145; 50268-696; 71610-259; 70518-3104; 50458-596; 70518-1771; 63552-180; 71161-132; 70518-0364; 0615-8196; 57451-1185; 69238-2112; 27241-003; 70518-3087; 13668-037; 12496-0120; 65757-727; 63415-0037; 55154-3361; 65862-167; 65841-670; 55154-5899; 43547-341; 50090-2780; 65841-642; 55111-470; 50458-308; 13668-036; 68084-274; 13668-038; 55289-519; 63304-951; 71610-045; 69238-2108; 68084-277; 65841-669; 54838-563; 55111-206; 50458-355; 70518-1613; 50268-695; 59746-030; 61919-572; 71335-0459; 65841-667; 71335-0626; 70518-1151; 50458-300; 55289-465; 27241-005; 65841-122; 50458-395; 68788-7211; 68084-273; 65862-365; 65757-726; 50090-3340 |
| Synonyms |
Risperidone | Risperdal Consta | Consta, Risperdal | Risperidal | R-64,766 | R 64,766 | R64,766 | R-64766 | R 64766 | R64766 |
