Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Sudden cardiac death
ADR ID BADD_A04830
ADR Hierarchy
02      Cardiac disorders
02.03      Cardiac arrhythmias
02.03.04      Ventricular arrhythmias and cardiac arrest
02.03.04.016      Sudden cardiac death
08      General disorders and administration site conditions
08.04      Fatal outcomes
08.04.01      Death and sudden death
08.04.01.008      Sudden cardiac death
Description Unexpected rapid natural death due to cardiovascular collapse within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as CHEST PAIN and CARDIAC ARRHYTHMIAS, particularly VENTRICULAR TACHYCARDIA, can lead to the loss of consciousness and cardiac arrest followed by biological death. (from Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 7th ed., 2005) | Sudden suspension of cardiac activity that is usually due to ARRHYTHMIA, in contrast to heart attack (MYOCARDIAL INFARCTION) which occurs due to blockage. The sudden suspension of cardiac activity generally requires RESUSCITATION. [MeSH]
MedDRA Code 10049418
MeSH ID D016757
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Sudden cardiac death | Sudden arrhythmic death syndrome | Death, Sudden, Cardiac | Sudden Cardiac Death | Cardiac Death, Sudden | Death, Sudden Cardiac | Cardiac Sudden Death | Death, Cardiac Sudden | Sudden Death, Cardiac | Sudden Cardiac Arrest | Arrest, Sudden Cardiac | Cardiac Arrests, Sudden | Cardiac Arrest, Sudden
ADR Related Proteins
Protein Name UniProt AC TTD Target ID
Potassium voltage-gated channel subfamily E member 1P15382Not Available
Potassium voltage-gated channel subfamily H member 2Q12809T20251
Potassium voltage-gated channel subfamily KQT member 1P51787T49526
Sodium channel protein type 5 subunit alphaQ14524T39716
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00073Aliskiren--
BADD_D00085Alprazolam--
BADD_D00100Ambrisentan--
BADD_D00115Amiodarone--
BADD_D00165Aripiprazole--
BADD_D00285Bosentan--
BADD_D00349Capecitabine--
BADD_D00367Carfilzomib--
BADD_D00410Celecoxib--
BADD_D00475Citalopram--
BADD_D00504Clopidogrel--
BADD_D00511Clozapine--
BADD_D00564Dabigatran etexilate--
BADD_D00794Ergocalciferol--
BADD_D00809Escitalopram--
BADD_D00979Furosemide--
BADD_D01038Goserelin--
BADD_D01119Ibrutinib--
BADD_D01136Imatinib--
BADD_D01253Lenalidomide--
BADD_D01261Leuprolide monoacetate--
BADD_D01275Levofloxacin--
BADD_D01336Macitentan--
BADD_D01401Metformin--
BADD_D01405Methadone--
BADD_D01431Methylphenidate--
BADD_D01445Metoprolol--
BADD_D01507Mycophenolate mofetil--
BADD_D01566Nifedipine--
BADD_D01567Nilotinib--
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