Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Metoprolol
Drug ID BADD_D01445
Description Metoprolol is a selective beta-1 blocker commonly employed as the succinate and tartrate derivatives depending if the formulation is designed to be of immediate release or extended release.[A175159, L5530] The possibility of the generation of these formulations comes from the lower systemic bioavailability of the succinate derivative.[T274] To this date, it is one of the preferred beta-blockers in general clinical guidelines and it is widely prescribed in the Netherlands, New Zealand, and the US.[A175162] Metoprolol was developed since 1969 by US Pharmaceutical Holdings I and FDA approved in 1978.[L5527]
Indications and Usage For the management of acute myocardial infarction, angina pectoris, heart failure and mild to moderate hypertension. May be used to treat supraventricular and tachyarrhythmias and as prophylaxis for migraine headaches.
Marketing Status Discontinued; Prescription
ATC Code C07AB02
DrugBank ID DB00264
KEGG ID D02358
MeSH ID D008790
PubChem ID 4171
NDC Product Code 0615-8422; 71205-003; 46708-291; 62332-113; 46708-292; 62332-114; 0615-8423; 62207-970; 62332-112; 65977-0117; 0615-8421; 46708-290
Synonyms Metoprolol | Toprol | Betaloc | Betaloc-Astra | Betaloc Astra | Betalok | CGP-2175 | CGP 2175 | CGP2175 | H 93-26 | H 93 26 | H 9326 | Metoprolol Tartrate | Seloken | Spesicor | Spesikor | Metoprolol Succinate | Metoprolol CR-XL | Metoprolol CR XL | Toprol-XL | Toprol XL | Beloc-Duriles | Beloc Duriles | Lopressor
Chemical Information
Molecular Formula C15H25NO3
CAS Registry Number 51384-51-1
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Adverse drug reactionCytochrome P450 2D6P10635T57392Not Available
Poisoning and toxicityCytochrome P450 2D6P10635T57392Not Available
Sudden cardiac deathPotassium voltage-gated channel subfamily E member 1P15382Not Available9927398; 10810773; 10082151; 10408028
Sudden cardiac deathPotassium voltage-gated channel subfamily H member 2Q12809T202519927398; 10810773; 10082151; 10408028
Sudden cardiac deathPotassium voltage-gated channel subfamily KQT member 1P51787T495269927398; 10810773; 10082151; 10408028
Sudden cardiac deathSodium channel protein type 5 subunit alphaQ14524T397169927398; 10810773; 10082151; 10408028
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.003--
Abnormal dreams19.02.03.001; Available
Abnormal faeces07.01.03.0010.000047%Not Available
Abnormal palmar/plantar creases23.07.04.016; Available
Abortion spontaneous18.01.04.001--Not Available
Abscess11.01.08.0010.000047%Not Available
Actinic keratosis23.01.06.0010.000140%Not Available
Acute hepatic failure09.01.03.0010.000008%Not Available
Acute myocardial infarction24.04.04.001; Available
Acute respiratory distress syndrome22.01.03.0010.000049%
Acute respiratory failure22.02.06.001; Available
Adrenocortical insufficiency acute14.11.01.020; Available
Agranulocytosis01.02.03.001--Not Available
Alanine aminotransferase increased13.03.01.003--
Altered state of consciousness19.07.01.003; Available
Alveolitis22.01.01.0010.000047%Not Available
Anaphylactic reaction24.06.03.006;
Anaphylactic shock24.06.02.004; Available
Aneurysm24.02.01.0010.000028%Not Available
Angina pectoris24.04.04.002;
Angioedema10.01.05.009; Available
Anhedonia19.15.02.007--Not Available
Ankle fracture15.08.03.005;
The 1th Page    1 2 3 4 5    Next   Last    Total 21 Pages