| Drug Name |
Ergocalciferol |
| Drug ID |
BADD_D00794 |
| Description |
Ergocalciferol is an inactivated vitamin D analog.[A177526] It is synthesized by some plants in the presence of UVB light.[T577] The production of ergocalciferol was prompted by the identification of dietary deficiency, more specifically vitamin D, as the main causative factor for the development of rickets. Ergocalciferol was isolated for the first time from yeast in 1931 and its structure was elucidated in 1932.[T580]
Ergocalciferol is considered the first vitamin D analog and is differentiated from [cholecalciferol] by the presence of a double bond between C22 and C23 and the presence of a methyl group at C24. These modifications reduce the affinity of ergocalciferol for the vitamin D binding protein resulting in faster clearance, limits its activation, and alters its catabolism.[A177637]
The first approved product containing ergocalciferol under the FDA records was developed by US Pharm Holdings and was FDA approved in 1941.[L6058] |
| Indications and Usage |
For use in the management of hypocalcemia and its clinical manifestations in patients with hypoparathyroidism, as well as for the treatment of familial hypophosphatemia (vitamin D resistant rickets). This drug has also been used in the treatment of nutritional rickets or osteomalacia, vitamin D dependent rickets, rickets or osteomalacia secondary to long-term high dose anticonvulsant therapy, early renal osteodystrophy, osteoporosis (in conjunction with calcium), and hypophosphatemia associated with Fanconi syndrome (with treatment of acidosis). |
| Marketing Status |
Prescription; Discontinued |
| ATC Code |
A11CC01 |
| DrugBank ID |
DB00153
|
| KEGG ID |
D00187
|
| MeSH ID |
D004872
|
| PubChem ID |
5280793
|
| TTD Drug ID |
D06JPB
|
| NDC Product Code |
60760-152; 49452-2760; 71335-1449; 68071-1951; 30698-493; 43353-219; 69452-151; 70518-0177; 43353-238; 68071-2352; 71335-0278; 71610-552; 10888-0140; 11014-0052; 60687-500; 63629-2447; 63629-7942; 71335-1699; 71335-0062; 68788-7627; 68071-2295; 42291-266; 50090-4382; 68071-1864; 11014-0026; 62332-464; 23155-809; 64980-157; 51407-143; 63187-519; 70934-252; 70518-1878; 43063-711; 51364-0007; 10888-8131; 64380-737; 63187-064; 66499-0041; 71335-1275; 50268-297; 71610-240; 63629-8144 |
| Synonyms |
Ergocalciferols | Calciferols | Vitamin D 2 | Vitamin D2 | D2, Vitamin | Ergocalciferol |
