Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Bupivacaine
Drug ID BADD_D00308
Description Bupivacaine is a widely used local anesthetic agent.
Indications and Usage Bupivacaine is indicated for the production of local or regional anesthesia or analgesia for surgery, for oral surgery procedures, for diagnostic and therapeutic procedures, and for obstetrical procedures. Bupivacaine is indicated to induce post-surgical analgesia in adults for up to 72 hours following arthroscopic subacromial decompression by administration into the subacromial space under direct arthroscopic visualization.[L31423] Bupivacaine, together with the NSAID [meloxicam], is indicated for the production of postsurgical analgesia in adult patients for up to 72 hours following bunionectomy, open inguinal herniorrhaphy or total knee arthroplasty.[L34100]
Marketing Status approved; investigational
ATC Code N01BB01
DrugBank ID DB00297
KEGG ID D07552
MeSH ID D002045
PubChem ID 2474
TTD Drug ID D0A0FL
NDC Product Code 52945-069; 59014-0053; 65250-133; 51715-660; 57884-0038; 65250-260; 49396-6601; 65250-266; 17381-024; 72640-017; 81371-5040
UNII Y8335394RO
Synonyms Bupivacaine | 1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide | Marcain | Bupivacain Janapharm | Bupivacain-RPR | Bupivacain RPR | Bupivacaina Braun | Carbostesin | Bupivacaine Carbonate | Bupivacaine Hydrochloride | Bupivacaine Monohydrochloride, Monohydrate | Buvacaina | Dolanaest | Sensorcaine | Svedocain Sin Vasoconstr | Marcaine | Bupivacaine Anhydrous
Chemical Information
Molecular Formula C18H28N2O
CAS Registry Number 38396-39-3
SMILES CCCCN1CCCCC1C(=O)NC2=C(C=CC=C2C)C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Acidosis14.01.03.002--
Aggression19.05.01.0010.000357%Not Available
Agitation19.06.02.001; 17.02.05.012--
Alanine aminotransferase increased13.03.04.005--
Anaemia01.03.02.001--
Anaphylactic shock24.06.02.004; 10.01.07.0020.000268%Not Available
Anaphylactoid reaction24.06.03.007; 10.01.07.003--Not Available
Anger19.04.02.0010.000268%Not Available
Angina pectoris02.02.02.002; 24.04.04.002--
Angioedema22.04.02.008; 23.04.01.001; 10.01.05.009--Not Available
Anterior spinal artery syndrome24.04.06.015; 17.10.01.008--Not Available
Anxiety19.06.02.002--
Aphonia22.12.03.001; 19.19.01.002; 17.02.08.009--
Apnoea22.02.01.0010.000179%
Application site erythema12.07.01.001; 08.02.01.001; 23.03.06.0050.000607%Not Available
Arachnoiditis17.06.01.001; 12.02.04.002--
Arrhythmia02.03.02.0010.000357%Not Available
Arthralgia15.01.02.001--
Aspartate aminotransferase increased13.03.04.011--
Asthenia08.01.01.001--Not Available
Atelectasis22.01.02.0010.000536%
Atrial fibrillation02.03.03.0020.000625%
Atrioventricular block02.03.01.0020.000179%Not Available
Atrioventricular block complete02.03.01.0030.000357%
Back pain15.03.04.005--
Blood creatinine increased13.13.01.004--
Blood pressure increased13.14.03.005--Not Available
Body temperature increased13.15.01.001--Not Available
Bone disorder15.02.04.004--Not Available
Bradycardia02.03.02.0020.000982%Not Available
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