| ADR Ontology |
| ADR Term |
Thrombotic thrombocytopenic purpura |
| ADR ID |
BADD_A04288 |
| ADR Hierarchy |
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| Description |
A disorder characterized by the presence of microangiopathic hemolytic anemia, thrombocytopenic purpura, fever, renal abnormalities and neurological abnormalities such as seizures, hemiplegia, and visual disturbances. It is an acute or subacute condition. [CTCAE] An acquired, congenital, or familial disorder caused by PLATELET AGGREGATION with THROMBOSIS in terminal arterioles and capillaries. Clinical features include THROMBOCYTOPENIA; HEMOLYTIC ANEMIA; AZOTEMIA; FEVER; and thrombotic microangiopathy. The classical form also includes neurological symptoms and end-organ damage, such as RENAL FAILURE. Mutations in the ADAMTS13 PROTEIN gene have been identified in familial cases. [MeSH] |
| MedDRA Code |
10043648 |
| MeSH ID |
D011697; D011697; D011697
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ADR Severity Grade (FAERS)
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ADR Severity Grade (CTCAE)
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| Synonym |
| Purpura thrombopaenic thrombotic | Purpura thrombopenic thrombotic | Thrombocytopenic purpura, thrombotic | Thrombotic thrombocytopenic purpura | TTP | Moschcowitz syndrome | Purpura, Thrombotic Thrombocytopenic | Thrombocytopenic Purpura, Thrombotic | Thrombotic Thrombocytopenic Purpura | Purpura, Thrombotic Thrombopenic | Thrombopenic Purpura, Thrombotic | Thrombotic Thrombopenic Purpura | Moschcowitz Disease | Moschkowitz Disease | Congenital Thrombotic Thrombocytopenic Purpura | Schulman-Upshaw Syndrome | Schulman Upshaw Syndrome | Upshaw-Schulman Syndrome | Upshaw Schulman Syndrome | Thrombotic Thrombocytopenic Purpura, Congenital | Upshaw Factor, Deficiency of | Microangiopathic Hemolytic Anemia, Congenital | Thrombotic Microangiopathy, Familial | Familial Thrombotic Microangiopathy | Microangiopathy, Familial Thrombotic | Familial Thrombotic Thrombocytopenic Purpura | Thrombotic Thrombocytopenic Purpura, Familial | Familial Thrombotic Thrombocytopenia Purpura |
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| ADR Related Proteins |
| Protein Name |
UniProt AC |
TTD Target ID |
| Not Available | Not Available | Not Available |
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| Drugs Leading to the ADR |
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