Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Clopidogrel bisulfate
Drug ID BADD_D00505
Description Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke.[A180508,L7213] Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recent MI, stroke, or established peripheral arterial disease,[L7213] It has been shown to be superior to [aspirin] in reducing cardiovascular outcomes in patients with cardiovascular disease and provides additional benefit to patients with acute coronary syndromes already taking aspirin.[A180547] Clopidogrel was granted FDA approval on 17 November 1997.[L7213]
Indications and Usage Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recent MI, stroke, or established peripheral arterial disease,[L7213]
Marketing Status approved
ATC Code B01AC04
DrugBank ID DB00758
KEGG ID D00769
MeSH ID D000077144
PubChem ID 115366
TTD Drug ID D0N0TZ
NDC Product Code 0904-6467; 50268-184; 53002-1672; 12666-0019; 50370-0040; 53104-7582; 77777-109; 50090-5330; 77771-121; 51552-1612; 60505-3992; 64220-103; 50228-121; 50228-124; 55154-3376; 60505-3532; 69367-194; 71205-073; 71335-1232; 77771-124; 65862-357; 71859-002; 13668-141; 63187-639; 64980-343; 68084-752; 42765-004; 65862-372; 73680-0002; 50090-2082; 55111-196; 60505-0253; 63629-8045; 68071-5277; 70518-1898; 0615-8014; 0904-6294; 14501-0026; 66577-037; 68578-0014; 68084-536; 68645-590; 69844-036; 68166-005; 71796-027; 72640-009; 43063-371; 55111-671; 63739-178; 71093-142; 71335-1646; 62147-0007; 73377-236; 69367-200; 71610-527; 50379-0015; 51407-032; 58118-0357; 68788-7700; 71335-0080; 82009-021; 53360-1171; 63310-2440; 71052-296; 47335-894; 50090-1301
UNII 08I79HTP27
Synonyms Clopidogrel | SC 25989C | SC 25990C | SR 25989 | Clopidogrel-Mepha | Clopidogrel Mepha | Clopidogrel Sandoz | Iscover | Clopidogrel Napadisilate | Clopidogrel Hydrochloride | PCR 4099 | PCR-4099 | Clopidogrel Besylate | Clopidogrel Besilate | Clopidogrel, (+)(S)-isomer | Plavix | Clopidogrel Bisulfate
Chemical Information
Molecular Formula C16H18ClNO6S2
CAS Registry Number 120202-66-6
SMILES COC(=O)C(C1=CC=CC=C1Cl)N2CCC3=C(C2)C=CS3.OS(=O)(=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice.
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Acute hepatic failure09.01.03.001---
Agranulocytosis01.02.03.001---
Anaphylactoid reaction24.06.03.007; 10.01.07.003---
Angioedema23.04.01.001; 10.01.05.009; 22.04.02.008---
Aplastic anaemia01.03.03.002---
Arthralgia15.01.02.001--
Arthritis15.01.01.001--
Blindness06.02.10.003; 17.17.01.003---
Blood creatinine increased13.13.01.004--
Bronchospasm10.01.03.012; 22.03.01.004--
Cerebral haemorrhage24.07.04.001; 17.08.01.003---
Colitis07.08.01.001--
Colitis ulcerative10.02.01.004; 07.08.01.005---
Confusional state19.13.01.001; 17.02.03.005--
Conjunctival haemorrhage24.07.05.001; 06.07.01.001---
Death08.04.01.001--
Dermatitis bullous23.03.01.002--
Diarrhoea07.02.01.001--
Disability26.01.01.003---
Duodenal ulcer07.04.02.002--
Dysgeusia17.02.07.003; 07.14.03.001--
Eczema23.03.04.006--
Eosinophilic pneumonia22.01.01.004; 01.02.04.003---
Epistaxis22.04.03.001; 24.07.01.005--
Erythema multiforme23.03.01.003; 10.01.03.015--
Eye haemorrhage12.02.02.012; 24.07.05.002; 06.07.02.001---
Gastric ulcer07.04.03.002--
Gastrointestinal haemorrhage24.07.02.009; 07.12.02.001---
Haematoma24.07.01.001--
Haematuria21.10.01.018; 24.07.01.047; 20.02.01.006--
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