| ADR Ontology |
| ADR Term |
Macular fibrosis |
| ADR ID |
BADD_A06659 |
| ADR Hierarchy |
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| Description |
A membrane on the vitreal surface of the retina resulting from the proliferation of one or more of three retinal elements: (1) fibrous astrocytes; (2) fibrocytes; and (3) retinal pigment epithelial cells. Localized epiretinal membranes may occur at the posterior pole of the eye without clinical signs or may cause marked loss of vision as a result of covering, distorting, or detaching the fovea centralis. Epiretinal membranes may cause vascular leakage and secondary retinal edema. In younger individuals some membranes appear to be developmental in origin and occur in otherwise normal eyes. The majority occur in association with retinal holes, ocular concussions, retinal inflammation, or after ocular surgery. (Newell, Ophthalmology: Principles and Concepts, 7th ed, p291) [MeSH] |
| MedDRA Code |
10071392 |
| MeSH ID |
D019773
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ADR Severity Grade (FAERS)
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ADR Severity Grade (CTCAE)
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Not Available
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| Synonym |
| Macular puckering of retina | Epimacular membrane | Macular puckering | Premacular gliosis | Preretinal fibrosis | Epiretinal membrane | Premacular membrane | Macular fibrosis | Internal limiting membrane wrinkling | Epiretinal Membrane | Epiretinal Membranes | Membrane, Epiretinal | Membranes, Epiretinal |
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| ADR Related Proteins |
| Protein Name |
UniProt AC |
TTD Target ID |
| Not Available | Not Available | Not Available |
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| Drugs Leading to the ADR |
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