Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tafluprost
Drug ID BADD_D02108
Description A prostaglandin analogue ester prodrug used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension. Chemically, tafluprost is a fluorinated analog of prostaglandin F2-alpha. Tafluprost was approved for use in the U.S. on February 10, 2012.
Indications and Usage Tafluprost is indicated for reducing elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension.
Marketing Status Prescription
ATC Code S01EE05
DrugBank ID DB08819
KEGG ID D06274
MeSH ID C485333
PubChem ID 9868491
TTD Drug ID D04LCQ
NDC Product Code 61556-080; 63190-0590; 54893-0021; 76397-013; 70390-0001; 65035-137; 75872-0001; 68245-0012; 17478-609
Synonyms tafluprost | 1-methylethyl (5Z)-7-((1R,2R, 3R,5S)-2-((1E)-3,3-difluoro-4-phenoxy -1-butenyl)-3,5-dihydroxycyclopentyl)-5-heptenoate | AFP-168
Chemical Information
Molecular Formula C25H34F2O5
CAS Registry Number 209860-87-7
SMILES CC(C)OC(=O)CCCC=CCC1C(CC(C1C=CC(COC2=CC=CC=C2)(F)F)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abnormal sensation in eye06.01.01.0010.000976%Not Available
Alopecia23.02.02.0010.000488%
Arthralgia15.01.02.0010.001220%
Asthma10.01.03.010; 22.03.01.002--Not Available
Blepharal pigmentation23.05.01.009; 06.06.04.0140.000488%Not Available
Burning sensation17.02.06.001; 08.01.09.0290.000488%Not Available
Cataract06.06.01.001--
Conjunctivitis allergic10.01.04.002; 06.04.01.003--Not Available
Cough22.02.03.0010.000488%
Death08.04.01.001--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.0040.000976%
Dry eye06.08.02.0010.000488%
Dysgeusia17.02.07.003; 07.14.03.0010.000732%
Dyspnoea22.02.01.004; 02.01.03.002--
Endophthalmitis11.01.06.003; 06.04.05.009--
Erythema23.03.06.0010.000976%Not Available
Erythema of eyelid23.03.06.006; 06.04.04.0030.000976%Not Available
Eye discharge06.04.05.0010.000976%Not Available
Eye disorder06.08.03.001--Not Available
Eye haemorrhage24.07.05.002; 06.07.02.0010.000488%Not Available
Eye inflammation06.04.05.0020.000488%Not Available
Eye irritation06.04.05.0030.005610%Not Available
Eye pain06.08.03.0020.003659%
Eye swelling06.08.03.0030.001707%Not Available
Eyelid oedema23.04.01.003; 10.01.05.001; 06.04.04.004--Not Available
Headache17.14.01.0010.002683%
Intraocular pressure increased13.07.04.0020.000488%Not Available
Iritis10.02.01.022; 06.04.03.002--Not Available
Lacrimation increased06.08.02.0040.000732%
Lymphoma16.20.01.001; 01.12.01.0010.000127%Not Available
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