Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Fluocinolone acetonide
Drug ID BADD_D00924
Description Fluocinolone acetonide, with the formula 6-alpha, 9-alpha-difluoro-16-alpha, 17 alpha-acetonide, is a corticosteroid that presents a high lipophilicity.[T357] It has been used extensively in dermatological preparations and it has also been investigated thoroughly for its use in implantable corticosteroid devices.[T358] This type of device containing fluocinolone acetonide was developed by Taro Pharmaceuticals and approved by FDA in May 2016.[L4676]
Indications and Usage For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Also for the treatment of chronic non-infectious uveitis affecting the posterior segment of the eye (Retisert).
Marketing Status Prescription; Discontinued
ATC Code C05AA10; D07AC04; S01BA15; S02BA08
DrugBank ID DB00591
KEGG ID D01825
MeSH ID D005446
PubChem ID 6215
TTD Drug ID D02QJH
NDC Product Code 64980-331; 63629-8655; 51927-0150; 68462-185; 0299-5500; 46439-8709; 64980-330; 51672-1365; 10135-670; 43538-911; 70752-159; 68791-101; 24208-416; 65162-704; 53183-0261; 49452-3156; 68462-591; 65162-703; 43538-900; 0168-0064; 71879-136; 65162-702; 43538-920; 71161-134; 0713-0709; 45802-887; 68791-102; 45802-485; 0395-8243; 43386-069; 43538-910; 71428-002; 70752-158; 0713-0223; 76420-163; 45802-009; 43538-921; 39328-079; 70752-156; 43538-901; 51672-1357; 68611-190; 0713-0224; 68791-103; 63629-8656; 51672-1356; 38779-0022; 68462-590
Synonyms Fluocinolone Acetonide | Acetonide, Fluocinolone | Fluortriamcinolone Acetonide | Acetonide, Fluortriamcinolone | Flurosyn | Jellin | Jellisoft | Synalar | Synalar-HP | Synalar HP | Synemol | Synamol | Alvadermo | Capex | Co-Fluocin | Co Fluocin | Cortiespec | Derma-Smooth FS | Derma Smooth FS | Flucinar | Fluocid | Fluodermo | Fluonid | Fluotrex | Flusolgen | Gelidina
Chemical Information
Molecular Formula C24H30F2O6
CAS Registry Number 67-73-2
SMILES CC1(OC2CC3C4CC(C5=CC(=O)C=CC5(C4(C(CC3(C2(O1)C(=O)CO)C)O)F)C)F)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abscess11.01.08.001--Not Available
Alopecia23.02.02.001--
Anaphylactic reaction24.06.03.006; 10.01.07.0010.001532%
Angle closure glaucoma06.03.01.0010.001532%Not Available
Arthralgia15.01.02.001--
Back pain15.03.04.005--
Blepharitis23.03.04.012; 06.04.04.001--Not Available
Blindness17.17.01.003; 06.02.02.0010.005361%Not Available
Body temperature increased13.15.01.001--Not Available
Burning sensation17.02.06.001; 08.01.09.029--Not Available
Cataract06.06.01.0010.004595%
Cataract subcapsular06.06.01.002--Not Available
Choroidal detachment12.01.04.006; 06.09.01.003--Not Available
Condition aggravated08.01.03.004--Not Available
Conjunctival haemorrhage24.07.05.001; 06.07.01.001--Not Available
Conjunctival oedema06.04.01.001--Not Available
Corneal oedema06.04.02.0010.009956%Not Available
Cough22.02.03.001--
Deafness neurosensory17.04.07.001; 04.02.01.002--Not Available
Death08.04.01.001--
Dermatitis23.03.04.002--Not Available
Dermatitis acneiform23.02.01.004--
Dermatitis atopic23.03.04.016; 10.01.04.004--Not Available
Dermatitis contact23.03.04.004; 12.03.01.040; 10.01.01.003--Not Available
Device expulsion27.01.01.002--Not Available
Diabetic retinal oedema14.07.01.001; 06.04.06.001; 05.07.01.0010.002297%Not Available
Diarrhoea07.02.01.001--
Diplopia17.17.01.005; 06.02.06.002--Not Available
Discomfort08.01.08.0030.001532%Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
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