Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Topiramate
Drug ID BADD_D02247
Description Topiramate is a anti-epileptic drug used to manage seizures and prevent migraines.[A175249] It was initially approved by the FDA in 1996. In 2004, topiramate was approved for the prevention of migraine in adults.[A188309,L10544] Since 2012, the extended-release formulation has been approved in combination with [phentermine] for chronic weight management therapy in adults.[L10550] Characteristics that distinguish topiramate from other antiepileptic drugs are a monosaccharide chemical structure containing a sulfamate, and 40% of its mass accounted for by oxygen.[A175249] Interestingly, topiramate was discovered by chance when attempts were made to formulate a novel antidiabetic drug.[A188330]
Indications and Usage Used for the treatment and control of partial seizures and severe tonic-clonic (grand mal) seizures and also for the prevention of migraine headaches. In children it is also used for treatment of Lennox-Gastaut syndrome. Qsymia® is indicated for the treatment and management of obesity.
Marketing Status Prescription; Discontinued
ATC Code N03AX11
DrugBank ID DB00273
KEGG ID D00537
MeSH ID D000077236
PubChem ID 5284627
TTD Drug ID D07VDZ
NDC Product Code 17772-103; 68071-4877; 68071-3012; 68382-141; 50090-3926; 16571-705; 61919-825; 50090-3932; 61919-439; 63187-228; 50458-645; 0245-1072; 63187-758; 60760-577; 0904-6929; 31722-183; 51655-606; 43063-734; 69217-070; 55700-596; 69097-816; 68071-3088; 71335-0047; 70518-2001; 13668-032; 71610-193; 0904-6928; 76282-279; 61919-369; 60760-094; 50379-0007; 53104-7532; 31722-184; 16571-708; 69097-817; 13668-034; 70518-2899; 70518-0233; 11014-0145; 11014-0305; 70934-768; 11014-0136; 63187-801; 50090-4614; 29300-115; 71610-493; 68382-864; 0245-1073; 70934-772; 76282-278; 11014-0308; 60760-514; 43602-459; 50090-3389; 68071-4793; 66039-806; 65862-173; 68788-7568; 65862-172; 61919-679; 60760-075; 0832-1071; 60429-770; 55154-7146; 50458-647; 70934-733; 0832-1073; 45865-551; 65862-171; 71610-492; 63629-4947; 65841-650; 70518-1674; 12658-0587; 68071-5165; 63187-963; 49452-7827; 69097-122; 60429-771; 71335-0548; 70518-2322; 70518-2498; 17205-096; 68382-138; 0093-7335; 68382-140; 50458-642; 55289-433; 70518-2104; 61919-883; 71610-485; 11014-0306; 60429-772; 65841-134; 69097-818; 71052-315; 0093-7336; 47335-707; 63187-059; 68382-139; 12502-4677; 69097-123; 50090-5853; 70518-2517; 80425-0092; 68788-7351; 63187-060; 65841-651; 68382-769; 68071-1971; 16571-707; 68084-343; 70518-2419; 68382-863; 43602-458; 11014-0137; 71205-233; 11014-0146; 11014-0110; 11014-0147; 70771-1317; 63187-118; 71335-0359; 13668-031; 71205-187; 11014-0307; 11014-0148; 70518-1651; 50090-3461; 65841-649; 0245-1075; 65977-0095; 51655-429; 43063-729; 65977-0008; 51927-4671; 55700-217; 61919-817; 50458-639; 71335-1147; 71335-1684; 43353-695; 68462-373; 0245-1074; 65862-174; 11014-0135; 71205-214; 63187-773; 51927-0149; 63187-696; 55700-227; 16571-706; 68462-110; 71335-0325; 62756-711; 70518-1503; 0832-1074; 29300-117; 68382-005; 43063-573; 65862-383; 70518-2391; 53808-1132; 47335-711; 63187-077; 70518-1180; 68084-344; 70518-2753; 70934-133; 52652-9001; 71335-0487; 65841-652; 55154-7142; 63187-283; 17772-101; 0832-1075; 51552-1206; 61919-318; 61919-172; 69097-124; 68788-7460; 50090-3752; 43602-460; 11014-0149; 76282-280; 70771-1315; 69097-125; 43063-997; 45865-459; 11014-0134; 68071-4756; 47335-712; 70518-0625; 29300-118; 43063-612; 70518-0887; 68382-004; 71335-1064; 0832-1072; 55700-894; 68462-370; 50090-5309; 68462-153; 55700-226; 68071-3196; 72789-004; 68071-5125; 13668-033; 43063-605; 62756-707; 55700-691; 71335-0337; 0245-1071; 63629-6871; 70518-2955; 68462-374; 0615-8139; 70518-1718; 61919-824; 43353-696; 31722-181; 71335-1116; 53808-1131; 63187-479; 69097-819; 17772-104; 68084-345; 50458-640; 68071-1612; 70518-1196; 61919-823; 43063-735; 55700-228; 68788-6770; 68462-108; 68462-372; 71205-202; 65841-648; 71205-195; 29300-116; 71335-1143; 68084-342; 43063-998; 50458-641; 70518-1937; 62756-710; 43353-697; 50090-3931; 70518-3067; 65129-1024; 68071-4760; 76282-281; 70771-1316; 17772-102; 38779-2443; 68788-7468; 65841-647; 31722-182; 71335-0499; 70518-1953; 68462-109; 70934-149; 0615-8140; 65267-103; 47335-710; 43602-457; 71610-486; 45865-963; 68462-371; 60429-769; 62756-712; 0615-8138
Synonyms Topiramate | 2,3-4,5-bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate | Epitomax | McN 4853 | McN-4853 | McN4853 | USL255 | Topamax
Chemical Information
Molecular Formula C12H21NO8S
CAS Registry Number 97240-79-4
SMILES CC1(OC2COC3(C(C2O1)OC(O3)(C)C)COS(=O)(=O)N)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Weight decreasedGalanin peptidesP22466T6787712700690; 11165308; 10840138; 12431850
Weight decreasedPro-neuropeptide YP01303T5167112700690; 11165308; 10840138; 12431850
Weight decreasedCorticoliberinP01143Not Available12700690; 11165308; 10840138; 12431850
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.002--
Abdominal pain lower07.01.05.010--Not Available
Abdominal pain upper07.01.05.003--
Abdominal tenderness07.01.05.004--Not Available
Abnormal dreams17.15.02.001; 19.02.03.001--Not Available
Abnormal sensation in eye06.01.01.0010.000239%Not Available
Abortion18.01.01.0010.000239%Not Available
Abortion spontaneous18.01.04.0010.002631%Not Available
Accommodation disorder06.02.04.0010.000239%Not Available
Acidosis14.01.03.0020.001316%
Acidosis hyperchloraemic14.01.01.0070.000478%Not Available
Acne23.02.01.001--Not Available
Activated partial thromboplastin time prolonged13.01.02.0010.000239%
Acute hepatic failure09.01.03.001--Not Available
Acute respiratory failure22.02.06.001; 14.01.04.004--Not Available
Administration site reaction12.07.04.011; 08.02.04.011--Not Available
Affective disorder19.04.04.0010.001435%Not Available
Ageusia17.02.07.001; 07.14.03.003--Not Available
Aggression19.05.01.0010.001555%Not Available
Agitation19.06.02.001; 17.02.05.0120.002392%
Agitation neonatal19.06.02.007; 18.04.04.002; 17.02.05.0280.000598%Not Available
Agranulocytosis01.02.03.0010.000598%Not Available
Akinesia17.01.02.003--Not Available
Alanine aminotransferase increased13.03.01.003--
Albuminuria20.02.01.001--Not Available
Alcohol intolerance14.02.01.001--
Alcoholism19.07.02.0010.000239%Not Available
Alopecia23.02.02.0010.006220%
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