Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Retinal tear
ADR ID BADD_A03858
ADR Hierarchy
06      Eye disorders
06.09      Ocular structural change, deposit and degeneration NEC
06.09.03      Retinal structural change, deposit and degeneration
06.09.03.010      Retinal tear
12      Injury, poisoning and procedural complications
12.01      Injuries NEC
12.01.04      Eye injuries NEC
12.01.04.014      Retinal tear
Description A disorder characterized by a small laceration of the retina, this occurs when the vitreous separates from the retina. Symptoms include flashes and floaters. [CTCAE] Perforations through the whole thickness of the retina including the macula as the result of inflammation, trauma, degeneration, etc. The concept includes retinal breaks, tears, dialyses, and holes. [MeSH]
MedDRA Code 10038897
MeSH ID D012167; D012167; D012167
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Horseshoe tear of retina without detachment | Multiple defects of retina without detachment | Retinal tear | Retinal tear (excl detachment) | Round hole of retina without detachment | Retinal break | Retinal hole | Retinal Perforations | Perforation, Retinal | Perforations, Retinal | Retinal Perforation | Retinal Holes | Hole, Retinal | Holes, Retinal | Retinal Hole | Retinal Dialyses | Dialyses, Retinal | Retinal Dialyse | Retinal Tears | Retinal Tear | Tear, Retinal | Tears, Retinal | Retinal Breaks | Break, Retinal | Breaks, Retinal | Retinal Break | Macular Holes | Hole, Macular | Holes, Macular | Macular Hole
ADR Related Proteins
Protein Name UniProt AC TTD Target ID
Not AvailableNot AvailableNot Available
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00048Aflibercept--
BADD_D00066Alendronic acid0.000505%
BADD_D00156Apremilast0.001158%
BADD_D00623Dexamethasone0.000687%
BADD_D00667Difluprednate0.000965%
BADD_D00680Dimethyl fumarate0.002751%
BADD_D00782Epinephrine0.000386%
BADD_D01136Imatinib0.000799%
BADD_D01253Lenalidomide0.001737%
BADD_D01352Maraviroc--
BADD_D01594Ocriplasmin--
BADD_D01687Pazopanib0.001865%
BADD_D01690Pegaptanib--
BADD_D01834Prednisone0.000040%
BADD_D02018Sildenafil0.000554%
BADD_D02031Sitaxentan--
BADD_D02236Tofacitinib0.001737%
BADD_D02331Valsartan0.000232%
BADD_D02464Fingolimod0.002316%
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