Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Pegaptanib
Drug ID BADD_D01690
Description Pegaptanib is a polynucleotide aptamer. Pegatinib aids neovascular age-related macular degeneration by binding to VEGF which in order reduces angiogenesis and vessel permeability. Pegaptanib was granted FDA approval on 17 September 2004.[L17903]
Indications and Usage For the treatment of neovascular (wet) age-related macular degeneration.
Marketing Status Prescription
ATC Code S01LA03
DrugBank ID DB04895
KEGG ID D05386
MeSH ID C495058
PubChem ID 56603655
TTD Drug ID D0UF9W
NDC Product Code Not Available
Synonyms pegaptanib | Macugen | pegaptanib sodium
Chemical Information
Molecular Formula C22H44N3O10P
CAS Registry Number 222716-86-1
SMILES COCCOC(=O)NCCCCC(C(=O)NCCCCCCCOP(=O)(C)O)NC(=O)OCCOC
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abnormal sensation in eye06.01.01.001--Not Available
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Anaphylactoid reaction10.01.07.003; 24.06.03.007--Not Available
Angioedema23.04.01.001; 10.01.05.009--Not Available
Aortic aneurysm24.02.03.001--Not Available
Arthritis15.01.01.001--
Asthenia08.01.01.001--Not Available
Asthenopia06.01.01.002--Not Available
Back pain15.03.04.005--
Blepharitis23.03.04.012; 06.04.04.001--Not Available
Bronchitis22.07.01.001; 11.01.09.001--
Cataract06.06.01.001--
Cataract traumatic12.01.04.008; 06.11.01.002--Not Available
Cerebrovascular accident17.08.01.007; 24.03.05.001--
Chalazion06.04.04.002--Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Chills15.05.03.016; 08.01.09.001--
Conjunctival haemorrhage06.07.01.001; 24.07.05.001--Not Available
Conjunctival oedema06.04.01.001--Not Available
Conjunctivitis11.01.06.012; 06.04.01.002--
Conjunctivitis allergic10.01.04.002; 06.04.01.003--Not Available
Corneal abrasion12.01.04.001; 06.11.03.001--Not Available
Corneal deposits06.06.03.002--Not Available
Corneal dystrophy06.13.03.001; 03.01.06.001--Not Available
Corneal epithelium defect06.06.03.012--Not Available
Corneal erosion06.06.03.003--Not Available
Corneal oedema06.04.02.001--Not Available
Deafness04.02.01.001--Not Available
Deposit eye06.09.04.005--Not Available
Dermatitis23.03.04.002--Not Available
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