Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Difluprednate
Drug ID BADD_D00667
Description Difluprednate is a topical corticosteroid indicated for the treatment of infammation and pain associated with ocular surgery. It is a butyrate ester of 6(α), 9(α)-difluoro prednisolone acetate. Difluprednate is abbreviated DFBA, or difluoroprednisolone butyrate acetate. It is indicated for treatment of endogenous anterior uveiti.
Indications and Usage For the treatment of inflammation and pain associated with ocular surgery.
Marketing Status Prescription
ATC Code D07AC19
DrugBank ID DB06781
KEGG ID D01266
MeSH ID C015808
PubChem ID 443936
TTD Drug ID D01ZOG
NDC Product Code 49803-002; 46439-8738; 26251-0003; 46439-8739; 69097-341; 76282-708
Synonyms difluprednate | ENV905 | C.M.9155 | Epitopic
Chemical Information
Molecular Formula C27H34F2O7
CAS Registry Number 23674-86-4
SMILES CCCC(=O)OC1(CCC2C1(CC(C3(C2CC(C4=CC(=O)C=CC43C)F)F)O)C)C(=O)COC(=O)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Application site irritation12.07.01.003; 08.02.01.003--Not Available
Blepharitis06.04.04.001; 23.03.04.012--Not Available
Blindness17.17.01.003; 06.02.02.0010.000965%Not Available
Cataract06.06.01.0010.001447%
Cataract subcapsular06.06.01.002--Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.0070.000965%
Chromatopsia06.02.05.0010.000965%Not Available
Cleft palate07.05.08.001; 03.04.02.001--Not Available
Conjunctival oedema06.04.01.001--Not Available
Corneal abrasion12.01.04.001; 06.11.03.0010.000965%Not Available
Corneal dystrophy06.13.03.001; 03.01.06.0010.000965%Not Available
Corneal epithelium defect06.06.03.0120.001447%Not Available
Corneal oedema06.04.02.0010.002412%Not Available
Corneal pigmentation06.06.03.013--Not Available
Dry eye06.08.02.0010.000965%
Endophthalmitis11.01.06.003; 06.04.05.009--
Episcleritis10.02.01.024; 06.04.07.001--Not Available
Eye disorder06.08.03.0010.001447%Not Available
Eye infection11.01.06.001; 06.04.05.007--
Eye inflammation06.04.05.0020.002894%Not Available
Eye irritation06.04.05.0030.007718%Not Available
Eye pain06.08.03.0020.009165%
Eye swelling06.08.03.0030.001447%Not Available
Eyelid oedema23.04.01.003; 06.04.04.004; 10.01.05.0010.001447%Not Available
Eyelid ptosis17.17.02.004; 06.05.01.0020.000965%Not Available
Fatigue08.01.01.002--
Gastrointestinal haemorrhage24.07.02.009; 07.12.02.0010.000965%Not Available
Glaucoma06.03.01.0020.001447%
Headache17.14.01.0010.001930%
Herpes simplex23.09.03.001; 11.05.02.001--Not Available
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