Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Ocriplasmin
Drug ID BADD_D01594
Description Ocriplasmin is a recombinant truncated form of human plasmin with a molecular weight of 27.2 kDa produced by recombinant DNA technology in a Pichia pastoris expression system. Ocriplasmin is a protein made up of 249 amino acids and has two peptide chains. Agent for pharmacologic vitreolysis; thrombolytic agent. FDA approved in October 17, 2012.
Indications and Usage Ocriplasmin is a proteolytic enzyme indicated for the treatment for symptomatic vitreomacular adhesion.
Marketing Status Prescription
ATC Code S01XA22
DrugBank ID DB08888
KEGG ID D09646
MeSH ID C054561
PubChem ID Not Available
TTD Drug ID Not Available
NDC Product Code Not Available
Synonyms microplasmin | ocriplasmin
Chemical Information
Molecular Formula Not Available
CAS Registry Number 1048016-09-6
SMILES Not Available
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Cataract06.06.01.001--
Chromatopsia06.02.05.001--Not Available
Conjunctival haemorrhage24.07.05.001; 06.07.01.001--Not Available
Dry eye06.08.02.001--
Eye pain06.08.03.002--
Intraocular pressure increased13.07.04.002--Not Available
Iritis10.02.01.022; 06.04.03.002--Not Available
Lens dislocation12.01.04.019; 06.06.05.004--Not Available
Macular oedema06.04.06.005--Not Available
Night blindness14.12.03.001; 06.02.02.003--
Photophobia06.01.01.004; 17.17.02.006--
Photopsia17.17.01.006; 06.02.06.004--
Pupillary reflex impaired17.02.11.007; 06.05.03.009--Not Available
Retinal degeneration06.09.03.002--Not Available
Retinal oedema24.03.07.006; 06.04.06.007--Not Available
Retinal tear12.01.04.014; 06.09.03.010--
Vision blurred17.17.01.010; 06.02.06.007--
Visual acuity reduced17.17.01.011; 06.02.03.001--
Visual impairment06.02.06.008--Not Available
Vitreous detachment12.01.04.005; 06.09.01.002--Not Available
Vitreous floaters06.09.01.005--
Macular hole06.09.03.009--Not Available
Conjunctival hyperaemia06.04.01.004--Not Available
Ocular discomfort06.08.03.008--Not Available
Anterior chamber cell06.04.10.001--Not Available
Cystoid macular oedema06.04.06.010; 12.02.02.005--Not Available
Metamorphopsia17.17.01.020; 06.02.06.014--Not Available
Intravitreal implant25.11.01.002--Not Available
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