Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Maraviroc
Drug ID BADD_D01352
Description Maraviroc (brand-named Selzentry, or Celsentri outside the U.S.) is a chemokine receptor antagonist drug developed by the drug company Pfizer that is designed to act against HIV by interfering with the interaction between HIV and CCR5. It was originally labelled as UK-427857 during development but was assigned the Maraviroc name as it entered trials. It was approved for use by the FDA in August, 2007.
Indications and Usage For treatment-experienced adult patients infected with only CCR5-tropic HIV-1 detectable, who have evidence of viral replication and HIV-1 strains resistant to multiple antiretroviral agents.
Marketing Status Prescription
ATC Code J05AX09
DrugBank ID DB04835
KEGG ID D06670
MeSH ID D000077592
PubChem ID 3002977
TTD Drug ID D0NR6S
NDC Product Code 69037-0062; 49702-223; 50923-0414; 12828-0091; 49702-260; 49702-235; 69037-0061; 31722-579; 49702-233; 31722-580; 68554-0040; 49702-237; 76072-1019; 49702-224
Synonyms Maraviroc | 4,4-Difluoro-N-((1S)-3-(exo-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo(3.2.1)oct-8-yl)-1-phenylpropyl)cyclohexanecarboxamide | Selzentry | UK-427,857 | UK 427,857 | UK427,857 | UK-427857 | UK 427857 | UK427857
Chemical Information
Molecular Formula C29H41F2N5O
CAS Registry Number 376348-65-1
SMILES CC1=NN=C(N1C2CC3CCC(C2)N3CCC(C4=CC=CC=C4)NC(=O)C5CCC(CC5)(F)F)C(C)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.003--
Abscess sweat gland23.02.03.012; 11.01.12.015--Not Available
Acne23.02.01.001--Not Available
Acquired immunodeficiency syndrome11.05.17.007; 10.03.03.001--Not Available
Acute sinusitis11.01.13.012; 22.07.03.013--Not Available
Agranulocytosis01.02.03.001--Not Available
Alanine aminotransferase13.03.01.031--Not Available
Alanine aminotransferase increased13.03.01.003--
Alopecia23.02.02.001--
Altered state of consciousness19.07.01.003; 17.02.04.001--Not Available
Amnesia17.03.02.001; 19.20.01.001--
Amylase13.05.01.010--Not Available
Anaemia01.03.02.001--
Angina pectoris24.04.04.002; 02.02.02.002--
Angina unstable24.04.04.004; 02.02.02.004--Not Available
Anxiety19.06.02.002--
Areflexia17.02.01.001--Not Available
Arterial spasm24.04.02.0110.001447%Not Available
Arthropathy15.01.01.003--Not Available
Aspartate aminotransferase13.03.01.032--Not Available
Aspartate aminotransferase increased13.03.01.006--
Asthenia08.01.01.001--Not Available
Basal cell carcinoma23.08.02.001; 16.03.02.001--Not Available
Basedow's disease10.04.08.004; 06.09.04.003; 05.02.02.003--Not Available
Benign neoplasm of skin23.10.01.006; 16.26.01.006--Not Available
Bile duct cancer16.07.01.001; 09.04.02.001--Not Available
Blood bilirubin13.03.01.040--Not Available
Blood creatine phosphokinase13.04.01.009--Not Available
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